Plasmonic nanoplatforms: From surface‐enhanced Raman scattering sensing to biomedical applications,Journal of Raman Spectroscopy

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Plasmonic nanoplatforms: From surface‐enhanced Raman scattering sensing to biomedical applications
Journal of Raman Spectroscopy ( IF 2.4 ) Pub Date : 2020-12-12 , DOI: 10.1002/jrs.6056
Vanessa Cupil‐Garcia _{1,

2} , Pietro Strobbia _{1,

3} , Bridget M. Crawford _{1,

3} , Hsin‐Neng Wang _{1,

3} , Hoan Ngo _{1,

3} , Yang Liu _{1,

2} , Tuan Vo‐Dinh _{1,

2,

3}

Affiliation

In this work, we present an overview of the development and application of surface‐enhanced Raman scattering (SERS) and plasmonic nanoplatforms developed in our laboratory in recent years. We have developed a wide variety of plasmonics‐active substrates and nanoparticle‐based sensing platforms including inverse molecular sentinels (iMS) utilizing gold nanostars (AuNS) and nanorattle DNA sensors (NR). These platforms have been used for a wide variety of applications, such as monitoring genomic biomarkers in plants for renewable bioenergy research, point‐of‐care diagnostics of infectious diseases (dengue and malaria), and detection of cancer biomarkers for gastrointestinal and head and neck cancers. Applications of plasmonic AuNS in bioimaging, photothermal therapy (PTT), and immunotherapy are also presented. An interesting advance was the development of AuNS‐mediated PTT in combination with immunotherapy, a method referred to as Synergistic Immuno Photothermal Nanotherapy (SYMPHONY), which broadens and significantly enhances the efficacy of immunotherapy. This review highlights various applications of the unique plasmonics‐enabled sensing and therapeutic nanotechnologies that contribute to the lasting legacy of the discovery of SERS.

中文翻译：

等离子体纳米平台：从表面增强拉曼散射传感到生物医学应用

在这项工作中，我们概述了近年来在实验室中开发的表面增强拉曼散射（SERS）和等离子体纳米平台的开发和应用。我们已经开发了各种各样的等离激元活性底物和基于纳米粒子的传感平台，包括利用金纳米星（AuNS）和纳米ra DNA传感器（NR）的逆分子前哨（iMS）。这些平台已被广泛使用，例如监测植物中的基因组生物标志物以进行可再生生物能源研究，传染病（登革热和疟疾）的即时诊断，以及胃肠道和头颈部癌症生物标志物的检测。癌症。还介绍了等离子AuNS在生物成像，光热疗法（PTT）和免疫疗法中的应用。一项有趣的进展是AuNS介导的PTT与免疫疗法相结合的发展，这种方法被称为协同免疫光热纳米疗法（SYMPHONY），可扩大并显着提高免疫疗法的功效。这篇综述重点介绍了独特的等离子激元传感和治疗纳米技术的各种应用，这些技术为SERS的发现留下了持久的遗产。

更新日期：2021-02-15

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