Background

Insulin-like growth factor-1 (IGF-1) plays a key role in the pathogenesis of metabolic syndrome, which is in turn associated with asthma. Whether IGF-1 contributes to asthma causation or asthma severity is largely unknown.

Objective

To evaluate the relation between serum IGF-1 and asthma, asthma outcomes, and lung function in adults.

Methods

Cross-sectional study of 297,590 adults (aged 40-69 years) who participated in the United Kingdom Biobank, had no diagnosis of diabetes, and were not on insulin. Multivariable logistic or linear regression was used to analyze serum IGF-1 and physician-diagnosed asthma, current wheezing, asthma hospitalizations, and lung function measures (forced expiratory volume in 1 second [FEV1], forced vital capacity [FVC], and FEV1 to FVC ratio).

Results

Serum IGF-1 levels above the lowest quartile (Q1) were significantly associated with lower odds of asthma (adjusted odds ratio for fourth quartile [Q4] vs Q1 = 0.88; 95% confidence interval [CI], 0.85-0.91). Among the participants with asthma, IGF-1 levels above Q1 were significantly associated with lower odds of current wheezing (adjusted odds ratio for Q4 vs Q1 = 0.89; 95% CI, 0.83-0.96), but not with asthma hospitalizations. Serum IGF-1 was significantly and positively associated with FEV1 (b = 20.9 mL; 95% CI, 19.1-22.7) and FVC (b = 25.6 mL; 95% CI, 23.4-27.7), regardless of an asthma diagnosis; these associations were significant in men and women, with larger estimated effects in men.

Conclusion

In a large study of British adults, higher serum IGF-1 levels were associated with lower odds of asthma and current wheezing and higher FEV1 and FVC. Our findings suggest potential beneficial effects of circulating IGF-1 on asthma and asthma outcomes in adults.

中文翻译：

---

英国成年人血清胰岛素样生长因子 1、哮喘和肺功能

 背景

胰岛素样生长因子-1 (IGF-1) 在代谢综合征的发病机制中发挥着关键作用，而代谢综合征又与哮喘相关。 IGF-1 是否会导致哮喘或哮喘严重程度尚不清楚。

 客观的

评估成人血清 IGF-1 与哮喘、哮喘结局和肺功能之间的关系。

 方法

这项横断面研究纳入了英国生物银行的 297,590 名成年人（40-69 岁），他们没有被诊断出患有糖尿病，也没有服用胰岛素。使用多变量 Logistic 或线性回归分析血清 IGF-1 和医生诊断的哮喘、当前喘息、哮喘住院情况和肺功能测量（1 秒用力呼气量 [FEV1]、用力肺活量 [FVC] 和 FEV1 至用力肺活量比率）。

 结果

高于最低四分位数 (Q1) 的血清 IGF-1 水平与较低的哮喘发病率显着相关（调整第四四分位数 [Q4] 与 Q1 的比值比 = 0.88；95% 置信区间 [CI]，0.85-0.91）。在患有哮喘的参与者中，高于 Q1 的 IGF-1 水平与当前喘息的较低几率显着相关（Q4 与 Q1 的调整优势比 = 0.89；95% CI，0.83-0.96），但与哮喘住院治疗无关。无论哮喘诊断如何，血清 IGF-1 与 FEV1（b = 20.9 mL；95% CI，19.1-22.7）和 FVC（b = 25.6 mL；95% CI，23.4-27.7）呈显着正相关；这些关联在男性和女性中都很显着，估计对男性的影响更大。

 结论

在一项针对英国成年人的大型研究中，较高的血清 IGF-1 水平与较低的哮喘和当前喘息几率以及较高的 FEV1 和 FVC 相关。我们的研究结果表明循环 IGF-1 对成人哮喘和哮喘结局具有潜在的有益作用。