Catatonia is a syndrome that manifests in patients with mental disorders and general medical conditions. However, functional changes to the brain that cause catatonia remain unknown. In the present study, we used functional near-infrared spectroscopy (fNIRS) to assess spontaneous hemodynamic activities in the brain at the times of onset and resolution of catatonic symptoms in patients with catatonia. We used 22-channel and 49-channel fNIRS to examine hemodynamic activities in the prefrontal cortex (PFC), and both frontal and parietal cortices, respectively. A total of ten patients who were diagnosed with catatonia were included in the study. Resting state measurements were taken for five minutes at the time of the onset and resolution of catatonic symptoms. Analyses were performed for the prefrontal region and the motor cortex within the parietal-frontal region of the brain. Functional connectivity between the cerebral hemispheres was evaluated systematically based on spontaneous oscillation of Δ[HbO2]. In the PFC, the resting state functional connectivity (RSFC) was significantly lower in the catatonic state than in the eyes-closed non-catatonic state (p = 0.047). The study demonstrated that the RSFC in the PFC, measured using fNIRS, may be an objective indicator of the change in catatonic symptoms.

紧张症是一种表现在患有精神障碍和一般医疗状况的患者身上的综合征。然而，导致紧张症的大脑功能变化仍然未知。在本研究中，我们使用功能性近红外光谱 (fNIRS) 来评估紧张症患者紧张症状发作和缓解时大脑中的自发血流动力学活动。我们使用 22 通道和 49 通道 fNIRS 分别检查前额叶皮层 (PFC) 以及额叶和顶叶皮层的血流动力学活动。该研究共包括十名被诊断患有紧张症的患者。在紧张性症状发作和消退时进行五分钟的静息状态测量。对大脑顶叶区的前额叶区和运动皮层进行了分析。基于 Δ[HbO2] 的自发振荡系统地评估大脑半球之间的功能连接。在 PFC 中，紧张状态下的静息状态功能连接 (RSFC) 显着低于闭眼非紧张状态 (p = 0.047)。该研究表明，使用 fNIRS 测量的 PFC 中的 RSFC 可能是紧张症症状变化的客观指标。静息状态功能连接（RSFC）在紧张状态下显着低于闭眼非紧张状态（p = 0.047）。该研究表明，使用 fNIRS 测量的 PFC 中的 RSFC 可能是紧张症症状变化的客观指标。静息状态功能连接（RSFC）在紧张状态下显着低于闭眼非紧张状态（p = 0.047）。该研究表明，使用 fNIRS 测量的 PFC 中的 RSFC 可能是紧张症症状变化的客观指标。