Immunotherapy and targeted therapy have been particularly effective in treating tumors of the urinary system; however, the mechanisms of the Wnt family of proteins in the tumorigenesis, development, and immune response of urinary system tumors are not fully understood. Here, we show that the Wnt family was extensively upregulated in and impacted the prognosis of patients with prostate adenocarcinoma (PRAD) and bladder urothelial carcinoma (BLCA). Moreover, the Wnt family correlated with the levels of infiltrating immune cells, including B cells, CD4 + T cells, CD8 + T cells, neutrophils, macrophages, and dendritic cells. The expression levels of Wnt family members were closely related to neoantigens, the mismatch repair system (MMRS) and DNA methyltransferases, and the mutation rate was generally low. Wnt family members are potential biomarkers for precision immunotherapy of urinary system tumors.

免疫疗法和靶向疗法在治疗泌尿系统肿瘤方面特别有效；然而，Wnt蛋白家族在泌尿系统肿瘤的发生、发展和免疫反应中的机制尚不完全清楚。在这里，我们表明 Wnt 家族在前列腺腺癌 (PRAD) 和膀胱尿路上皮癌 (BLCA) 患者中广泛上调并影响其预后。此外，Wnt 家族与浸润性免疫细胞的水平相关，包括 B 细胞、CD4 + T 细胞、CD8 + T 细胞、中性粒细胞、巨噬细胞和树突状细胞。Wnt家族成员的表达水平与新抗原、错配修复系统（MMRS）和DNA甲基转移酶密切相关，突变率普遍较低。