ABSTRACT

Introduction

Clay minerals are a class of silicates with chemical inertness, colloid, and thixotropy, which have excellent physicochemical properties, good biocompatibility, low toxicity, and have high application potential in biomedical fields. These inorganic materials have been widely used in pharmaceutical excipients and active substances. In recent years, nanoclay mineral materials have been used as drug vehicles for the delivery of a variety of drugs based on their broad specific surface area, rich porosity, diverse morphology, good adsorption performance, and high ion exchange capacity.

Areas covered

This review introduces the structures, properties, and applications of various common natural and synthetic nanoclay materials as drug carriers. Natural nanoclays have different morphologies including nanoplates, nanotubes, and nanofibers. Synthetic materials have controllable sizes and flexible structures, where mesoporous silica nanoparticles, laponite, and imogolite are typical ones. These inorganic nanoparticles are often linked to polymers to form multifunctional drug delivery systems for better pharmaceutical performance.

Expert opinion

The clay nanomaterials have typical properties, including enhanced solubility of insoluble drugs, targeting therapeutic sites, controlled release, and stimulation of responsive drug delivery systems.

中文翻译：

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粘土纳米颗粒作为药物输送系统中的药物载体

摘要

介绍

粘土矿物是一类具有化学惰性、胶体性和触变性的硅酸盐，具有优良的理化性质、良好的生物相容性、低毒性，在生物医学领域具有很高的应用潜力。这些无机材料已广泛用于药用辅料和活性物质。近年来，纳米粘土矿物材料因其比表面积大、孔隙率高、形态多样、吸附性能好、离子交换能力强等特点，被用作药物载体，用于输送多种药物。

覆盖区域

本综述介绍了各种常见的天然和合成纳米粘土材料作为药物载体的结构、性质和应用。天然纳米粘土具有不同的形态，包括纳米片、纳米管和纳米纤维。合成材料具有可控的尺寸和灵活的结构，其中介孔二氧化硅纳米粒子、合成锂皂石和伊莫戈石是典型的材料。这些无机纳米粒子通常与聚合物相连，形成多功能药物递送系统，以获得更好的药物性能。

专家意见

粘土纳米材料具有典型的特性，包括增强不溶性药物的溶解度、靶向治疗位点、控释和刺激响应性药物递送系统。