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Phonophobia and brainstem excitability in migraine
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-12-10 , DOI: 10.1111/ejn.15078 Jayantee Kalita 1 , Usha K Misra 1 , Robin Bansal 1
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-12-10 , DOI: 10.1111/ejn.15078 Jayantee Kalita 1 , Usha K Misra 1 , Robin Bansal 1
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Phonophobia in migraineurs may be due to lower hearing threshold (HT) and higher brainstem neuronal excitability. We report the correlation of phonophobia in migraineurs with HT, brain stem auditory evoked potential (BAEP) findings, and auditory triggers. Sixty‐one migraineurs and 101 controls were included for HT, of whom 59 migraineurs and 31 controls had BAEP studies. Clinical details, migraine triggers, and headache frequency were noted. Hearing threshold was measured, and amplitudes of waves I to V of BAEP studies were measured. Migraineurs had lower HT compared with controls (41.61 ± 5.25 versus 45.39 ± 6.26 dB; p < 0.001) especially in chronic migraine (40.24 ± 4.81; p < 0.001). Hearing threshold correlated with headache frequency (p < 0.05) and auditory, visual, and tactile (p < 0.05) triggers. Hearing threshold was lower during headache (p < 0.001). Wave II, III, and IV amplitudes of BAEP were higher in migraineurs than the controls. Wave II (p < 0.05) and III (p < 0.05) amplitudes correlated with HT. Migraineurs have lower HT, especially in those having chronic migraine, ictal HT recording, and multiple sensory triggers. Higher amplitudes of BAEP waves in migraineurs and their relationship with the frequency of headache and HT suggest the sensitization of brainstem auditory neurons.
中文翻译：
偏头痛的恐惧症和脑干兴奋性
偏头痛的恐惧症可能是由于较低的听力阈值（HT）和较高的脑干神经元兴奋性所致。我们报告了与HT，脑干听觉诱发电位（BAEP）发现和听觉触发因素有关的偏头痛患者的恐惧心理。HT包括61个偏头痛患者和101个对照，其中59个偏头痛患者和31个对照进行了BAEP研究。记录临床细节，偏头痛触发因素和头痛频率。测量听力阈值，并测量BAEP研究的I至V波振幅。与对照组相比，偏头痛患者的HT较低（41.61±5.25对45.39±6.26 dB；p <0.001），尤其是在慢性偏头痛患者中（40.24±4.81; p <0.001）。听力阈值与头痛频率相关（p <0.05）以及听觉，视觉和触觉（p <0.05）触发因素。头痛期间的听力阈值较低（p <0.001）。在偏头痛患者中，BAEP的第二，第三和第四波幅度均高于对照组。波形II（p <0.05）和III（p <0.05）的振幅与HT相关。偏头痛患者的HT较低，尤其是那些患有慢性偏头痛，发作性HT记录和多种感觉触发因素的患者。偏头痛患者中BAEP波的更高幅度及其与头痛和HT频率的关系表明脑干听觉神经元敏感。
更新日期：2020-12-10
中文翻译：
偏头痛的恐惧症和脑干兴奋性
偏头痛的恐惧症可能是由于较低的听力阈值（HT）和较高的脑干神经元兴奋性所致。我们报告了与HT，脑干听觉诱发电位（BAEP）发现和听觉触发因素有关的偏头痛患者的恐惧心理。HT包括61个偏头痛患者和101个对照，其中59个偏头痛患者和31个对照进行了BAEP研究。记录临床细节，偏头痛触发因素和头痛频率。测量听力阈值，并测量BAEP研究的I至V波振幅。与对照组相比，偏头痛患者的HT较低（41.61±5.25对45.39±6.26 dB；p <0.001），尤其是在慢性偏头痛患者中（40.24±4.81; p <0.001）。听力阈值与头痛频率相关（p <0.05）以及听觉，视觉和触觉（p <0.05）触发因素。头痛期间的听力阈值较低（p <0.001）。在偏头痛患者中，BAEP的第二，第三和第四波幅度均高于对照组。波形II（p <0.05）和III（p <0.05）的振幅与HT相关。偏头痛患者的HT较低，尤其是那些患有慢性偏头痛，发作性HT记录和多种感觉触发因素的患者。偏头痛患者中BAEP波的更高幅度及其与头痛和HT频率的关系表明脑干听觉神经元敏感。
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