Neurodegenerative disorders such as Parkinson's and Alzheimer's disease, are fundamental health concerns all around the world. The development of novel treatments and new techniques to address these disorders, are being actively studied by researchers and medical personnel. In the present review we will discuss the application of induced Pluripotent Stem Cells (iPSCs) for cell-therapy replacement and disease modelling. The aim of iPSCs is to restore the functionality of the damaged tissue by replacing the impaired cells with competitive ones. To achieve this objective, iPSCs can be properly differentiated into virtually any cell fate and can be strongly translated into human health via in vitro and in vivo disease modeling for the development of new therapies, the discovery of biomarkers for several disorders, the elaboration and testing of new drugs as novel treatments, and as a tool for personalized medicine.

帕金森氏病和阿尔茨海默氏病等神经退行性疾病是全世界的基本健康问题。研究人员和医务人员正在积极研究开发针对这些疾病的新疗法和新技术。在本综述中，我们将讨论诱导多能干细胞（iPSC）在细胞疗法替代和疾病建模中的应用。iPSC的目的是通过用竞争性细胞替换受损的细胞来恢复受损组织的功能。为了实现这一目标，iPSC可以正确分化为几乎任何细胞命运，并可以通过体外和体内强烈转化为人类健康 疾病建模，用于开发新疗法，发现多种疾病的生物标志物，开发和测试作为新疗法的新药以及作为个性化药物的工具。