Abnormalities in the spectral power of offenders' neural oscillations have been noted within select Resting-State Networks (RSNs); however, no study has yet evaluated the influence of cocaine dependence, drug use severity, and psychopathic traits on these abnormalities. To this end, the present study compared rest-related power spectral characteristics between two groups of offenders (with and without a DSM-IV-TR cocaine-dependence diagnosis) and a non-offender control group. Results indicated that both offender groups presented with lower low frequency power ratio (LFPR) scores (i.e. across all RSNs) than non-offenders. These differences in LFPR scores were due to both higher high-frequency power (0.15-0.25 Hz; within seven (in non-dependent offenders) and five (in cocaine-dependent offenders) of eight investigated networks) and decreased low-frequency power (0.01-0.10 Hz; within six (in non-dependent offenders) and one (in cocaine-dependent offenders) of eight investigated networks) compared to non-offenders. Thus, both cocaine-dependent and non-dependent offenders displayed abnormal neural oscillations, suggesting that these oscillatory abnormalities could exist as neurobiological features associated with offender status. Offenders' LFPR levels correlated with lifetime years of cocaine use, but not with the level of psychopathic traits. These findings supplement our knowledge regarding the influence of substance use on resting-state activity in offenders; moreover, they provide further indication of the importance of evaluating shared/unique variance associated with drug use and pyschopathic personality traits.

中文翻译：

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反社会男性在休息期间的功率谱变化与可卡因依赖的关系：网络分析


在选定的静息态网络 (RSN) 中已注意到罪犯神经振荡频谱功率的异常；然而，尚无研究评估可卡因依赖、吸毒严重程度和精神病特征对这些异常的影响。为此，本研究比较了两组罪犯（有或没有 DSM-IV-TR 可卡因依赖诊断）和非罪犯对照组之间的休息相关功率谱特征。结果表明，两个犯罪者群体的低频功率比 (LFPR) 得分（即所有 RSN）均低于非犯罪者。 LFPR 分数的这些差异是由于较高的高频功率（0.15-0.25 Hz；在八个被调查网络的七个（非依赖性犯罪者）和五个（可卡因依赖性犯罪者）内）和低频功率降低（ 0.01-0.10 Hz；与非犯罪者相比，在 8 个被调查网络中的 6 个（非依赖性犯罪者）和 1 个（可卡因依赖性犯罪者）内。因此，可卡因依赖者和非可卡因依赖者都表现出异常的神经振荡，这表明这些振荡异常可能作为与犯罪者状态相关的神经生物学特征而存在。罪犯的 LFPR 水平与一生中使用可卡因的年数相关，但与精神病特征的水平无关。这些发现补充了我们关于药物使用对罪犯静息状态活动的影响的知识；此外，它们进一步表明了评估与吸毒和精神变态人格特征相关的共同/独特差异的重要性。