BACKGROUND Secondary use of routine medical data relies on a shared understanding of given information. This understanding is achieved through metadata and their interconnections, which can be stored in metadata repositories (MDRs). The necessity of an MDR is well understood, but the local work on metadata is a time-consuming and challenging process for domain experts. OBJECTIVE To support the identification, collection, and provision of metadata in a predefined structured manner to foster consolidation. A particular focus is placed on user acceptance. METHODS We propose a software pipeline MDRBridge as a practical intermediary for metadata capture and processing, based on MDRSheet, an ISO 11179-3 compliant template using popular spreadsheet software. It serves as a practical mediator for metadata acquisition and processing in a broader pipeline. Due to the different origins of the metadata, both manual entry and automatic extractions from application systems are supported. To enable the export of collected metadata into external MDRs, a mapping of ISO 11179 to Clinical Data Interchange Standards Consortium (CDISC) Operational Data Model (ODM) was developed. RESULTS MDRSheet is embedded in the processing pipeline MDRBridge and delivers metadata in the CDISC ODM format for further use in MDRs. This approach is used to interactively unify core datasets, import existing standard datasets, and automatically extract all defined data elements from source systems. The involvement of clinical domain experts improved significantly due to minimal changes within their usual work routine. CONCLUSION A high degree of acceptance was achieved by adapting the working methods of clinical domain experts. The designed process is capable of transforming all relevant data elements according to the ISO 11179-3 format. MDRSheet is used as an intermediate format to present the information at a glance and to allow editing or supplementing by domain experts.

中文翻译：

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距技术仅一步之遥，而向领域专家迈出的第一步— MDRBridge：基于模板的符合ISO 11179的元数据处理管道

背景技术常规医学数据的二次使用依赖于对给定信息的共同理解。可以通过元数据及其互连来实现这种理解，这些元数据及其互连可以存储在元数据存储库（MDR）中。MDR的必要性已广为人知，但对于元数据专家而言，本地元数据工作是一个耗时且具有挑战性的过程。目的以预定义的结构化方式支持元数据的标识，收集和提供，以促进合并。特别关注用户接受度。方法我们基于使用流行的电子表格软件的ISO 11179-3兼容模板MDRSheet，提出了一种软件管道MDRBridge作为用于元数据捕获和处理的实用中介。它充当更广泛管道中元数据获取和处理的实用中介。由于元数据的来源不同，因此支持从应用程序系统手动输入和自动提取。为了能够将收集的元数据导出到外部MDR中，开发了ISO 11179到临床数据交换标准协会（CDISC）操作数据模型（ODM）的映射。结果MDRSheet嵌入在处理管道MDRBridge中，并以CDISC ODM格式提供元数据，以便在MDR中进一步使用。该方法用于交互式地统一核心数据集，导入现有标准数据集并自动从源系统中提取所有定义的数据元素。由于他们日常工作中的变化很小，因此临床领域专家的参与得到了显着改善。结论通过适应临床领域专家的工作方法获得了高度认可。设计的过程能够根据ISO 11179-3格式转换所有相关的数据元素。MDRSheet用作中间格式，一目了然地显示信息，并允许域专家进行编辑或补充。