Thermoresponsive Hemostatic Hydrogel with a Biomimetic Nanostructure Constructed from Aggregated Collagen Nanofibers,Biomacromolecules

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Thermoresponsive Hemostatic Hydrogel with a Biomimetic Nanostructure Constructed from Aggregated Collagen Nanofibers
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-12-09 , DOI: 10.1021/acs.biomac.0c01167
Xinhua Liu _{1,

2,

3} , Mengdi Hou _{1,

2,

3} , Xiaomin Luo _{1,

2,

3} , Manhui Zheng _{1,

2,

3} , Xuechuan Wang _{1,

2,

3} , Huijie Zhang _{1,

2,

3} , Junling Guo _{4,

5}

Affiliation

Uncontrollable bleeding poses considerable fatality risks by large-volume blood losses. Current emergency antibleeding handlings including either compression with gauze or “passive” blood transfusion are thus far from ideal, while most recently developed hemostatic agents still share common limitations without considering the subsequent tissue repairing and antibacterial activity after treatment. Herein, we introduce a novel bioinspired aggregated collagen nanofiber-based biocompatible and efficient hemostatic hydrogel material (TS-Gel-Ag-col) prepared by the integration of multifunctional compounds of muco-mimetic poloxamer, polyvinylpyrrolidone, and dencichine/chitosan dialdehyde synergistic crosslinked aggregated collagen nanofibers decorated with silver nanoparticles. Comprehensive material characterization and in vitro and in vivo studies of TS-Gel-Ag-col demonstrate that these materials possess effective antihemorrhagic and antibacterial wound protection effects. Moreover, TS-Gel-Ag-col can facilitate the tissue repairing of skin wounds by promoting revascularization. TS-Gel-Ag-col holds great promise for next-generation collagen-based absorbable hemostatic materials and for the development of smart artificial skins.

中文翻译：

由仿生胶原纳米纤维构建的具有仿生纳米结构的热敏止血水凝胶。

大量失血会导致无法控制的出血，从而带来巨大的死亡风险。因此，当前的紧急止血处理（包括用纱布加压或“被动”输血）远非理想，而最新开发的止血剂仍具有共同的局限性，而未考虑治疗后的组织修复和抗菌活性。在这里，我们介绍了一种新型的生物启发的聚集的胶原蛋白纳米纤维为基础的生物相容性和高效止血水凝胶材料（TS-Gel-Ag-col），它是通过模拟粘液模拟的泊洛沙姆，聚乙烯吡咯烷酮和树胶素/壳聚糖二醛协同交联的聚集体的多功能化合物而制备的胶原纳米纤维装饰有银纳米颗粒。全面的材料表征和TS-Gel-Ag-col的体外和体内研究表明，这些材料具有有效的止血和抗菌伤口保护作用。而且，TS-Gel-Ag-col可以通过促进血管再生来促进皮肤伤口的组织修复。TS-Gel-Ag-col对于下一代基于胶原的可吸收止血材料以及智能人造皮肤的开发具有广阔的前景。

更新日期：2021-02-08

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