INTRODUCTION Obesity results from an imbalance in the intake and expenditure of calories that leads to lifestyle-related diseases. Although genome-wide association studies (GWAS) have revealed many obesity-related genetic factors, the interactions of these factors and calorie intake remain unknown. This study aimed to investigate interactions between calorie intake and the polygenic risk score (PRS) of BMI. METHODS Three cohorts, i.e., from the Korea Association REsource (KARE; n = 8,736), CArdioVAscular Disease Association Study (CAVAS; n = 9,334), and Health EXAminee (HEXA; n = 28,445), were used for this study. BMI-related genetic loci were selected from previous GWAS. Two scores, PRS, and association (a)PRS, were used; the former was determined from 193 single-nucleotide polymorphisms (SNPs) from 5 GWAS datasets, and the latter from 62 SNPs (potentially associated) from 3 Korean cohorts (meta-analysis, p < 0.01). RESULTS PRS and aPRS were significantly associated with BMI in all 3 cohorts but did not exhibit a significant interaction with total calorie intake. Similar results were obtained for obesity. PRS and aPRS were significantly associated with obesity but did not show a significant interaction with total calorie intake. We further analyzed the interaction with protein, fat, and carbohydrate intake. The results were similar to those for total calorie intake, with PRS and aPRS found to not be associated with the interaction of any of the 3 nutrition components for either BMI or obesity. DISCUSSION The interaction of BMI PRS with calorie intake was investigated in 3 independent Korean cohorts (total n = 35,094) and no interactions were found between PRS and calorie intake for obesity.

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韩国人群肥胖症多基因风险评分与卡路里摄入量的相互作用分析

引言 肥胖是由卡路里摄入和消耗不平衡导致的，从而导致与生活方式相关的疾病。尽管全基因组关联研究 (GWAS) 揭示了许多与肥胖相关的遗传因素，但这些因素与卡路里摄入量之间的相互作用仍然未知。本研究旨在调查卡路里摄入量与 BMI 的多基因风险评分 (PRS) 之间的相互作用。方法 本研究使用了来自韩国协会资源 (KARE；n = 8,736)、心血管疾病协会研究 (CAVAS；n = 9,334) 和 Health EXAminee (HEXA；n = 28,445) 的三个队列。BMI 相关基因位点选自之前的 GWAS。使用了两个分数，PRS 和关联 (a)PRS；前者是从 5 个 GWAS 数据集的 193 个单核苷酸多态性 (SNP) 中确定的，后者来自 3 个韩国队列的 62 个 SNP（潜在相关）（荟萃分析，p < 0.01）。结果 PRS 和 aPRS 在所有 3 个队列中都与 BMI 显着相关，但与总卡路里摄入量没有显着的相互作用。肥胖也获得了类似的结果。PRS 和 aPRS 与肥胖显着相关，但与总卡路里摄入量没有显着相互作用。我们进一步分析了与蛋白质、脂肪和碳水化合物摄入量的相互作用。结果与总卡路里摄入量的结果相似，发现 PRS 和 aPRS 与 BMI 或肥胖的 3 种营养成分中的任何一种的相互作用无关。讨论 在 3 个独立的韩国队列（总共 n = 35，