Abstract

The synthesis of drug delivery systems based on hollow mesoporous silica nanoparticles (MSNs) is still a major challenge. In this work, the hollow hybrid MSNs were successfully prepared by cetyltrimethylammonium bromide-directed sol − gel process and one-step hydrothermal treatment process. The hollow hybrid MSNs had hybrid ethane bridged frameworks with the uniform particle size (250 nm) and mesoporous pore diameter (3.7 nm). The polyacrylic acid (PAA) encapsulated drug delivery system based on hollow hybrid MSNs was prepared by using silanization, surface modification, doxorubicin hydrochloride (DOX) loading, and PAA coating. Drug encapsulation and release behavior at different temperatures and pH were studied by using DOX as a model guest molecule. The results displayed that the modified hollow ethane bridged MSNs possessed good biocompatibility and excellent thermal/pH-dual sensitive drug release property. This novel thermal/pH-sensitive drug delivery system based on hollow ethane bridged MSNs has the advantages of feasible synthesis, no cytotoxicity, and good drug loading capacity, which may have potential applications in the anti-cancer therapy.

摘要

基于中空介孔二氧化硅纳米粒子（MSN）的药物递送系统的合成仍然是一项重大挑战。在这项工作中，通过十六烷基三甲基溴化铵定向溶胶-凝胶法和一步水热处理工艺成功制备了空心杂化MSN。中空杂化MSN具有杂化乙烷桥联骨架，具有均匀的粒径（250纳米）和中孔孔径（3.7纳米）。通过硅烷化，表面改性，盐酸阿霉素（DOX）负载和PAA涂层制备了基于空心杂化MSN的聚丙烯酸（PAA）封装的药物递送系统。通过使用DOX作为模型客体分子研究了在不同温度和pH下的药物包封和释放行为。结果表明，改性空心乙烷桥联的MSN具有良好的生物相容性和优异的热/ pH-双敏感药物释放性能。该新型基于空心乙烷桥联的MSN的热/ pH敏感药物递送系统具有合成可行，无细胞毒性和良好的载药量等优点，可能在抗癌治疗中具有潜在的应用前景。