Prostaglandins are critical lipid mediators involved in the wound healing response, with prostaglandin E₂ (PGE₂) being the most complex and exhibiting the most diverse physiological outputs. PGE₂ signals via four G-protein coupled receptors, termed EP-receptors 1-4, that induce distinct signaling pathways upon activation and lead to an array of different outputs. Recent studies examining the role of PGE₂ and EP receptor signaling in wound healing following various forms of tissue damage are discussed in this review.

中文翻译：

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前列腺素 E2-EP 受体信号在伤口愈合中的复杂作用

前列腺素是参与伤口愈合反应的关键脂质介质，其中前列腺素 E ₂ (PGE ₂ ) 是最复杂的并且表现出最多样化的生理输出。PGE ₂通过称为 EP 受体 1-4 的四种 G 蛋白偶联受体发出信号，这些受体在激活时诱导不同的信号通路并导致一系列不同的输出。本综述讨论了最近研究 PGE ₂和 EP 受体信号在各种形式的组织损伤后伤口愈合中的作用。