Mucosal damage is a key feature of inflammatory bowel diseases (IBD) and healing of the mucosa is an endpoint of IBD treatment that is often difficult to achieve. Autonomic neurons of the parasympathetic and sympathetic nervous system may influence intestinal epithelial cell growth and modulating epithelial innervation could for that reason serve as an interesting therapeutic option to improve mucosal healing. Understanding of the biological processes triggered by nonspecific and specific epithelial adrenergic and cholinergic receptor activation is of key importance. At present, with rising technological advances bioelectronics neuromodulation as treatment modality has gained momentum. We discuss the current view on state-of-the-art innervation of the intestinal crypt and its impact on epithelial cell growth and differentiation. Furthermore, we outline bioelectronic technology and review its relevance to wound healing processes.

中文翻译：

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肠道隐窝的神经元神经支配

粘膜损伤是炎症性肠病（IBD）的关键特征，粘膜愈合是IBD治疗的终点，通常难以实现。副交感神经和交感神经系统的自主神经元可能会影响肠上皮细胞的生长，因此，调节上皮神经支配可能成为改善粘膜愈合的有趣治疗选择。了解由非特异性和特异性上皮肾上腺素能和胆碱能受体激活引发的生物学过程至关重要。目前，随着技术的进步，随着治疗方式的发展，生物电子神经调节已获得发展势头。我们讨论了最新的肠隐窝神经支配及其对上皮细胞生长和分化的影响。此外，