Activation of nuclear factor‐κB in the angiogenesis of glioma: Insights into the associated molecular mechanisms and targeted therapies,Cell Proliferation

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Activation of nuclear factor‐κB in the angiogenesis of glioma: Insights into the associated molecular mechanisms and targeted therapies
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-12-10 , DOI: 10.1111/cpr.12929
Jiajie Tu ₁ , Yilong Fang ₁ , Dafei Han ₁ , Xuewen Tan ₁ , Haifeng Jiang ₁ , Xun Gong ₁ , Xinming Wang ₂ , Wenming Hong ₂ , Wei Wei ₁

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Glioma is the most commonly observed primary intracranial tumour and is associated with massive angiogenesis. Glioma neovascularization provides nutrients for the growth and metabolism of tumour tissues, promotes tumour cell division and proliferation, and provides conditions ideal for the infiltration and migration of tumour cells to distant places. Growing evidence suggests that there is a correlation between the activation of nuclear factor (NF)-κB and the angiogenesis of glioma. In this review article, we highlighted the functions of NF-κB in the angiogenesis of glioma, showing that NF-κB activation plays a pivotal role in the growth and progression of glioma angiogenesis and is a rational therapeutic target for antiangiogenic strategies aimed at glioma.

中文翻译：

神经胶质瘤血管生成中核因子-κB 的激活：深入了解相关分子机制和靶向治疗

胶质瘤是最常见的原发性颅内肿瘤，与大量血管生成有关。胶质瘤新生血管为肿瘤组织的生长和代谢提供营养，促进肿瘤细胞分裂和增殖，为肿瘤细胞向远处浸润和迁移提供了理想的条件。越来越多的证据表明，核因子 (NF)-κB 的激活与神经胶质瘤的血管生成之间存在相关性。在这篇综述文章中，我们强调了 NF-κB 在神经胶质瘤血管生成中的功能，表明 NF-κB 激活在神经胶质瘤血管生成的生长和进展中起着关键作用，并且是针对神经胶质瘤的抗血管生成策略的合理治疗靶点。

更新日期：2020-12-10

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