当前位置: X-MOL 学术Isr. J. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Fluorescent Sensors of Phosphate Containing Biomolecules
Israel Journal of Chemistry ( IF 2.3 ) Pub Date : 2020-12-09 , DOI: 10.1002/ijch.202000087
Arundhati Nag 1 , Samir Das 1
Affiliation  

Phosphates are an essential functional group in living organisms. Phosphates are required to synthesize ATP, the energy unit in cells, and the synthesis of DNA and RNA, phosphoproteins, phospholipids, and various metabolites. This article is focused on reviewing current research on fluorescent sensing of biologically relevant phosphate functionalities in an aqueous environment or more complex environments such as live cells. There are three different approaches for the fluorescent detection of phosphates. These involve using metal‐ligand complexes as sensors, using metal‐free small molecules as sensors, and using protein or peptide molecules as sensors. The utilization of these approaches for fluorescent sensing of different phosphate‐containing biomolecule classes such as nucleoside polyphosphates, phosphorylated peptides, phosphorylated proteins, pyrophosphates, phospholipids, and RNA are discussed.

中文翻译:

含磷酸盐的生物分子荧光传感器

磷酸盐是活生物体中必不可少的功能基团。磷酸是合成ATP,细胞中的能量单位以及DNA和RNA,磷蛋白,磷脂和各种代谢产物的合成所必需的。本文的重点是回顾当前在水性环境或更复杂的环境(例如活细胞)中对生物学相关的磷酸盐功能进行荧光传感的当前研究。有三种不同的荧光荧光检测方法。其中包括使用金属配体配合物作为传感器,使用无金属的小分子作为传感器,以及使用蛋白质或肽分子作为传感器。利用这些方法对不同的含磷酸盐的生物分子类别(例如核苷多磷酸盐,磷酸化肽,磷酸化蛋白,
更新日期:2020-12-09
down
wechat
bug