Acute promyelocytic leukemia (APL) is one of the most life-threatening hematological emergencies and requires a prompt correct diagnosis by cytomorphology and flow cytometry (FCM) with later confirmation by cytogenetics/molecular genetics. However, nucleophosmin 1 muted acute myeloid leukemia (NPM1+ AML) can mimic APL, especially the hypogranular variant of APL. Our study aimed to develop a novel, Radar plot-based FCM strategy to distinguish APLs and NPM1+ AMLs quickly and accurately.

中文翻译：

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雷达图有助于通过流式细胞术鉴别诊断急性早幼粒细胞白血病和 NPM1+ 急性髓细胞白血病

急性早幼粒细胞白血病 (APL) 是最危及生命的血液急症之一，需要通过细胞形态学和流式细胞术 (FCM) 及时正确诊断，随后通过细胞遗传学/分子遗传学确认。然而，核磷蛋白 1 减弱的急性髓细胞白血病 ( NPM1+ AML) 可以模拟 APL，尤其是 APL 的低颗粒变体。我们的研究旨在开发一种新颖的、基于雷达图的 FCM 策略，以快速准确地区分 APL 和NPM1+ AML。