Lithium‐induced overexpression of β‐catenin delays murine palatal shelf elevation by Cdc‐42 mediated F‐actin remodeling in mesenchymal cells,Birth Defects Research

当前位置： X-MOL 学术 › Birth Defects Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Lithium‐induced overexpression of β‐catenin delays murine palatal shelf elevation by Cdc‐42 mediated F‐actin remodeling in mesenchymal cells
Birth Defects Research ( IF 1.6 ) Pub Date : 2020-12-10 , DOI: 10.1002/bdr2.1853
Xiao-Ming Wang _{1,

2,

3} , Wei-Long Liu _{1,

2,

3} , Yu Chen _{1,

2,

3} , Xiao-Xiao Pang _{1,

2,

3} , Ya-Hong Wang _{1,

2,

3} , Min Wu ₄ , Bing Shi _{1,

2,

3} , Cheng-Hao Li _{1,

2,

3}

Affiliation

Lithium chloride (LiCl) is widely used for the treatment of manic and other psychotic disorders, but the administration of lithium can result in several congenital defects in the fetus, including cleft palate (Meng, Wang, Torensma, Jw & Bian, 2015) (Szabo, 1970). However, the mechanism of Lithium's action as a developmental toxicant in palatogenesis is not well known.

中文翻译：

锂诱导的β-连环蛋白过表达通过Cdc-42介导的间充质细胞中的F-肌动蛋白重塑延迟了鼠腭架升高

氯化锂 (LiCl) 被广泛用于治疗躁狂症和其他精神障碍，但服用锂会导致胎儿出现多种先天性缺陷，包括腭裂（Meng、Wang、Torensma、Jw 和 Bian，2015 年）（萨博，1970）。然而，锂在腭发生中作为发育毒物的作用机制尚不清楚。

更新日期：2020-12-10

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11