Abstract This study aimed to investigate the effect of a 12-week very low-carbohydrate, high-fat (VLCHF) diet and exercise on biomarkers of inflammation in healthy individuals. Since the anti-inflammatory effects of a ketogenic diet have been established, we hypothesized that the VLCHF diet, along with exercise, would have an additional favorable effect on biomarkers of inflammation. Twenty-four healthy individuals were allocated to the very low-carbohydrate, high-fat diet (VLCHF: N=12, age 25.3±2.0 years, body mass 66.7±9.8 kg, fat mass 21.5±4.9 %) or habitual diet (HD: N=12, age 23.9±3.8 years, body mass 72.7±15.0 kg, fat mass 23.4±8.4 %) group. Biomarkers of inflammation (adiponectin, leptin, and high-sensitive interleukin-6 [hs-IL-6]) and substrate metabolism (glycated hemoglobin, fasting glucose, triacylglycerides, and cholesterol) were analyzed from blood at baseline and after 12 weeks. The adiponectin-leptin ratio significantly increased in the VLCHF group after the intervention period (ES [95% CL]: -0.90 [-0.96, -0.77], p=

中文翻译：

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健康个体在 12 周极低碳水化合物、高脂肪饮食和运动训练后脂联素 - 瘦素比率增加：一项非随机、平行组研究

摘要 本研究旨在调查 12 周极低碳水化合物、高脂肪 (VLCHF) 饮食和运动对健康个体炎症生物标志物的影响。由于生酮饮食的抗炎作用已经确立，我们假设 VLCHF 饮食与运动一起，将对炎症的生物标志物产生额外的有利影响。24 名健康个体被分配到极低碳水化合物、高脂肪饮食（VLCHF：N=12，年龄 25.3±2.0 岁，体重 66.7±9.8 kg，脂肪量 21.5±4.9%）或习惯性饮食（HD ：N=12，年龄 23.9±3.8 岁，体重 72.7±15.0 kg，脂肪量 23.4±8.4 %) 组。炎症生物标志物（脂联素、瘦素和高敏白细胞介素 6 [hs-IL-6]）和底物代谢（糖化血红蛋白、空腹血糖、三酰甘油、和胆固醇）在基线和 12 周后从血液中进行分析。干预期后，VLCHF 组的脂联素-瘦素比率显着增加（ES [95% CL]：-0.90 [-0.96, -0.77]，p=