Abstract The route of a specific drug carrier system is always a significant platform of development that combines the principles of biomedical technology, nanotechnology, and pharmaceutical drug design. Transdermal (TD) drug delivery involves the release of the drug via the stratum corneum of the tissue membrane into the sustained release by diffusion across the epidermal layer. This method (often known as topical drug delivery) has increased noteworthy research enthusiasm in the course of recent decades due to its relatively simpler and non-invasive administration. Over the past few decades, considerable advancement was achieved in TD delivery and a number of drugs are now successfully reported. In this review, we focus on the progress regarding applications of important biopolymers described for the TD drug release applications and related aspects. Three mostly reported plant and animal-derived polymers (such as natural rubber, chitosan, and cellulose for the development of TD carrier system) were extensively analyzed. The general principle of TD drug delivery, advantages, and limitations of the works reported were also discussed.

中文翻译：

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用于透皮给药系统的天然高分子工程生物材料研究进展

摘要 特定药物载体系统的路线始终是结合生物医学技术、纳米技术和药物药物设计原理的重要开发平台。透皮 (TD) 药物递送涉及通过组织膜的角质层将药物释放到通过跨表皮层扩散的持续释放中。这种方法（通常称为局部给药）由于其相对简单和无创的给药方式，在近几十年来增加了值得注意的研究热情。在过去的几十年里，TD 递送取得了相当大的进步，现在已经成功报道了许多药物。在这次审查中，我们专注于为 TD 药物释放应用和相关方面描述的重要生物聚合物的应用进展。广泛分析了三种主要报道的植物和动物来源的聚合物（如天然橡胶、壳聚糖和纤维素，用于开发 TD 载体系统）。还讨论了 TD 药物递送的一般原则、优点和所报告工作的局限性。