Curd and yogurt is rich in protein, calcium, magnesium and other vitamins and considered as beneficial for diabetics. The present study delves into another aspect of curd and yogurt; viz. its role in protein glycation and thereby initiation of inflammation. Curd contains glyoxal and methylglyoxal and thereby capable of glycating proteins. The present study has used curd set for 12 h, 24 h and yogurt. Rats were fed 1.5 g curd and yogurt twice a day for 45 days. General and specific Advanced Glycation End Products (AGEs) were measured from various tissues showing 6.5, 10.5 and 11.5 fold increase in general fluorescence in the liver tissue in 12 h curd, yogurt and 24 h curd fed rats respectively. The specific fluorescence was even higher in liver and kidney. Likewise, enhanced AGEs formation was also observed in intestines, heart, lungs, lens, soleus muscle and pancreas. Animals demonstrated lower SOD value and higher catalase and TBARS implying oxidative stress. The extent of stress was as 24 h > yogurt > 12 h fed rats. IL-6, IL-10 and TNF-α values were found to increase in a similar pattern while that of IL-4 and IFN-γ were reduced. OGTT revealed an impaired glucose tolerance in 24 h curd fed rats and yogurt. In view of lesser effect of 12 h set curd, its effect on diabetic animals was studied, demonstrating an increase in AGEs in all the tissues. Hence regular consumption of curds can lead to glycation of proteins, inflammation and oxidative stress that can cause progression of diabetes.

凝乳和酸奶富含蛋白质，钙，镁和其他维生素，被认为对糖尿病患者有益。本研究深入研究了凝乳和酸奶的另一个方面。即 其在蛋白质糖基化中的作用，从而引发炎症。凝乳含有乙二醛和甲基乙二醛，因此能够糖化蛋白质。本研究使用凝乳凝固12小时，24小时和酸奶。每天两次给大鼠喂1.5 g凝乳和酸奶，持续45天。从各种组织中测得的普通和特定高级糖化终产物（AGEs）在分别喂食12 h凝乳，酸奶和24 h凝乳的大鼠的肝脏组织中显示出一般荧光增加6.5、10.5和11.5倍。肝和肾中的特异性荧光甚至更高。同样，在肠，心脏，肺，晶状体，比目鱼肌和胰腺。动物的SOD值较低，过氧化氢酶和TBARS较高，表明氧化应激。应激程度为24小时>酸奶> 12小时喂养的大鼠。发现IL-6，IL-10和TNF-α值以相似的方式增加，而IL-4和IFN-γ的值减少。OGTT揭示凝乳喂养的大鼠和酸奶在24小时内葡萄糖耐量受损。鉴于凝结凝乳12 h的作用较小，因此研究了其对糖尿病动物的作用，表明所有组织中AGEs均增加。因此，经常食用凝乳会导致蛋白质糖基化，炎症和氧化应激，从而导致糖尿病的发展。发现IL-10和TNF-α值以相似的模式增加，而IL-4和IFN-γ的值减少。OGTT揭示凝乳喂养的大鼠和酸奶在24小时内葡萄糖耐量受损。鉴于凝结凝乳12 h的作用较小，因此研究了其对糖尿病动物的作用，证明了所有组织中AGEs的增加。因此，经常食用凝乳会导致蛋白质糖基化，炎症和氧化应激，从而导致糖尿病的发展。发现IL-10和TNF-α值以相似的模式增加，而IL-4和IFN-γ的值减少。OGTT揭示凝乳喂养的大鼠和酸奶在24小时内葡萄糖耐量受损。鉴于凝结凝乳12 h的作用较小，因此研究了其对糖尿病动物的作用，证明了所有组织中AGEs的增加。因此，经常食用凝乳会导致蛋白质糖基化，炎症和氧化应激，从而导致糖尿病的发展。