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Distribution of enterovirus genotypes detected in clinical samples in Hungary, 2010-2018.
Acta Microbiologica et Immunologica Hungarica ( IF 1.3 ) Pub Date : 2020-12-05 , DOI: 10.1556/030.2020.01200
Erika Bujaki 1 , Ágnes Farkas 1 , Zita Rigó 1 , Mária Takács 1, 2
Affiliation  

This report provides the findings of a retrospective surveillance study on the emergence and circulation of enteroviruses with their associated clinical symptoms over a nine-year period detected at the National Enterovirus Reference Laboratory in Hungary between 2010-2018.Enterovirus (EV) detection and genotyping were performed directly from clinical samples. From 4,080 clinical specimens 25 EV types were identified with a median age of patients of 5 years and 68% of all cases affected children aged 10 years or younger, although infections occurred in all age-groups. In 130 cases neurological symptoms were recorded, in 123 cases the infection presented in skin related signs including hand, foot, and mouth disease (HFMD), herpangina and rash. In 2010 EV-A71 was found to cause the majority of diagnosed EV infections while in 2011 and from 2014-2018, Coxsackievirus (CV)-A6 was identified most often. Echovirus E6 accounted for the most cases in 2012 and Echovirus 30 dominated in 2013. EV-D68 was identified only in 2010 and 2013.Widespread circulation of several EV-A and EV-B viruses with occasional occurrence of EV-C and EV-D was detected. The ability of EVs to cause severe infections in sporadic cases and regular outbreaks highlight the importance of continued monitoring of circulating EV types.

中文翻译:

2010-2018 年匈牙利临床样本中检测到的肠道病毒基因型分布。

本报告提供了 2010 年至 2018 年间在匈牙利国家肠道病毒参考实验室检测到的 9 年期间肠道病毒及其相关临床症状的出现和传播的回顾性监测研究的结果。肠道病毒 (EV) 检测和基因分型是直接从临床样本中进行。从 4,080 份临床标本中确定了 25 种 EV 类型,患者的中位年龄为 5 岁,所有病例中有 68% 影响 10 岁或更小的儿童,尽管感染发生在所有年龄组。在 130 例中记录了神经系统症状,其中 123 例感染表现为皮肤相关体征,包括手足口病 (HFMD)、疱疹性咽峡炎和皮疹。2010 年发现 EV-A71 导致大多数确诊的 EV 感染,而在 2011 年和 2014-2018 年,柯萨奇病毒 (CV)-A6 最常被鉴定。Echovirus E6 占 2012 年的大多数病例,Echovirus 30 在 2013 年占主导地位。EV-D68 仅在 2010 年和 2013 年被发现。几种 EV-A 和 EV-B 病毒广泛传播,偶尔出现 EV-C 和 EV-D被检测到。EV 在散发病例和定期爆发中引起严重感染的能力凸显了持续监测循环 EV 类型的重要性。
更新日期:2020-12-11
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