Significance: Due to patients’ respiratory movement or involuntary body movements during breast cancer radiotherapy, the mismatched adjacent fields in surface exposure regions could result in insufficient dosage or overdose in these regions, which would lead to tissue injury, excessive skin burns, and potential death. Cherenkov luminescence imaging (CLI) could be used to effectively detect the matching information of adjacent radiation fields without extra radiation or invasive imaging. Aim: Our objective was to provide a biological experimental basis for monitoring matching of adjacent radiation fields between photon and electron fields due to introduced shifts during radiotherapy by CLI technique. Approach: A medical accelerator was used to generate photon and electron fields. An industrial camera system was adopted to image the excited CLI signal during irradiation of chicken tissue with yellow (group A and group C experiments) or black color (group B experiment). The following introduced shifts were tested: 10, 5, 2, and 0 mm toward superior or inferior direction. A model was introduced to deal with matching error analysis of adjacent radiation fields due to introduced shifts with adapted plans used to treat neoplasms of the right breast with supraclavicular nodes or internal mammary lymph node. Results: The matching values between photon and electron fields were consistent with the tested introduced shifts during yellow chicken irradiation. In group A, average discrepancies were 0.59 ± 0.35 mm and 0.68 ± 0.37 mm for photon fields and electron fields in anterior/posterior (AP) direction, with 87% and 75% of measurement within 1 mm, respectively. In group C, average discrepancies were 0.80 ± 0.65 mm and 1.07 ± 0.57 mm for oblique photon field with gantry angles of 330 deg and 150 deg, with 66% and 65% of measurement within 1 mm, respectively. The average discrepancies were 0.44 ± 0.30 mm for electron field in the AP direction, with 94% of measurement within 1 mm. The matching error introduced by the proposed method was less than 1.5 mm for AP fields and 2 mm for oblique incidence fields. However, the field matching could not be monitored with black chicken tissue irradiation due to a weak CLI signal that could hardly be extracted from background noise in group B. Conclusions: CLI is demonstrated for the quantitative monitoring of the field match line on light biological tissue phantoms and has potential for monitoring of field matching in surface tissue during breast cancer radiotherapy.

中文翻译：

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使用切伦科夫成像监测生物组织体模上光子和电子放射治疗场之间的匹配线

意义：在乳腺癌放疗过程中，由于患者的呼吸运动或不自主的身体运动，表面照射区域的相邻场不匹配可能导致这些区域的剂量不足或过量，从而导致组织损伤、皮肤过度灼伤，并可能导致死亡. 切伦科夫发光成像（CLI）可用于有效检测相邻辐射场的匹配信息，而无需额外辐射或侵入性成像。目的：我们的目标是为监测由于 CLI 技术在放射治疗期间引入的位移而导致的光子和电子场之间相邻辐射场的匹配提供生物学实验基础。方法：使用医疗加速器来产生光子和电子场。采用工业相机系统对鸡组织照射黄色（A组和C组实验）或黑色（B组实验）时激发的CLI信号进行成像。测试了以下引入的移位：向上或向下方向移动 10、5、2 和 0 毫米。引入了一个模型来处理相邻辐射场的匹配误差分析，因为引入了用于治疗具有锁骨上淋巴结或内乳淋巴结的右乳房肿瘤的适应计划。结果：光子和电子场之间的匹配值与黄鸡辐照期间测试引入的偏移一致。在 A 组中，前后 (AP) 方向的光子场和电子场的平均差异分别为 0.59 ± 0.35 mm 和 0.68 ± 0.37 mm，1 毫米内分别有 87% 和 75% 的测量值。在 C 组中，机架角度为 330 度和 150 度的倾斜光子场的平均差异分别为 0.80 ± 0.65 mm 和 1.07 ± 0.57 mm，分别有 66% 和 65% 的测量值在 1 mm 内。AP 方向的电子场的平均差异为 0.44 ± 0.30 毫米，94% 的测量值在 1 毫米以内。所提出的方法引入的匹配误差对于 AP 场小于 1.5 mm，对于斜入射场小于 2 mm。然而，由于 CLI 信号微弱，很难从 B 组的背景噪声中提取出来，因此无法用黑鸡组织照射监测场匹配。 结论：