NMR-based plasma metabolomics of adult B-cell acute lymphoblastic leukemia,Molecular Omics

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NMR-based plasma metabolomics of adult B-cell acute lymphoblastic leukemia
Molecular Omics ( IF 3.0 ) Pub Date : 2020-11-13 , DOI: 10.1039/d0mo00067a
Fengmin Yang ₁ , Qian Li , Junfeng Xiang , Hong Zhang , Hongxia Sun , Guorui Ruan , Yalin Tang

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Acute lymphoblastic leukemia (ALL) is one of the common malignant tumors. Compared with childhood ALL, the treatment effect of adult B-cell ALL is less effective and remains a big challenge. In order to explore the pathogenesis of adult B-cell ALL and find new diagnostic biomarkers to develop sensitive diagnostic tools, we investigated the plasma metabolites of adult B-cell ALL by using ¹H NMR (nuclear magnetic resonance) metabolomics. Relative to healthy controls, adult B-cell ALL patients showed abnormal metabolism, including glycolysis, gluconeogenesis, amino acid metabolism, fatty acid metabolism and choline phospholipid metabolism. What's more important, we also found that the optimal combination of choline, tyrosine and unsaturated lipids has the potential to diagnose and prognose adult B-cell ALL in the clinic.

中文翻译：

基于核磁共振的成人 B 细胞急性淋巴细胞白血病血浆代谢组学

急性淋巴细胞白血病（ALL）是常见的恶性肿瘤之一。与儿童 ALL 相比，成人 B 细胞 ALL 的治疗效果较差，仍然是一个很大的挑战。为了探索成人 B 细胞 ALL 的发病机制并寻找新的诊断生物标志物以开发灵敏的诊断工具，我们通过使用¹H NMR（核磁共振）代谢组学。相对于健康对照，成人 B 细胞 ALL 患者表现出异常代谢，包括糖酵解、糖异生、氨基酸代谢、脂肪酸代谢和胆碱磷脂代谢。更重要的是，我们还发现胆碱、酪氨酸和不饱和脂质的最佳组合具有诊断和预测临床成人 B 细胞 ALL 的潜力。

更新日期：2020-12-09

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