This report describes an open-air, screen-printed organic electrochemical transistor (OECT) fabricated on a paper substrate for the determination of halide ion concentrations within ranges relevant for human disease diagnosis. Chloride ions (Cl⁻) owing to their prevalence in biochemistry were specifically evaluated and the OECT’s efficacy with regards to measuring biologically relevant Cl⁻ concentrations in the presence of multiple cationic and anionic interference species was studied. Sensor response was evaluated using both bench-top measurements as well as with hybrid data processing and notification circuitry assembled on the same flexible paper substrate as the OECT. To simplify the measurement process, a current-to-voltage converter was screen-printed in series with the OECT channel to facilitate voltage measurements in direct correlation with the drain current modulations. The bio-electronic conductive polymer poly(3,4-ethylenedioxythiophene) poly(styrene sulphonate) (PEDOT:PSS) was utilized as the transistor channel and silver (Ag) was used as the halide-selective gate electrode. Finally, the paper OECT and the on-board hybrid circuitry were powered using Zn-MnO₂-ZnCl₂ based printed paper cells and the biosensor’s suitability towards distinguishing between Cl⁻ concentrations clinically associated with a diagnosis of cystic fibrosis was evaluated as a proof of concept. This work demonstrates a simple biosensing system working in the faradaic mode of operation without the implementation of selective ionophore films and incorporates aspects of recyclability, biodegradability and eco-friendliness.

该报告描述了一种在纸质基材上制造的开放式丝网印刷有机电化学晶体管（OECT），用于确定与人类疾病诊断相关的范围内的卤离子浓度。氯离子（CL ^- ）由于其在生物化学患病率具体评价和OECT与关于测量生物学相关氯功效^-研究了存在多种阳离子和阴离子干扰物质时的浓度。使用台式测量以及与OECT相同的柔性纸质基板上组装的混合数据处理和通知电路，评估了传感器的响应。为了简化测量过程，电流-电压转换器与OECT通道串联丝网印刷，以促进电压测量与漏极电流调制直接相关。生物电子导电聚合物聚（3,4-乙撑二氧噻吩）聚（苯乙烯磺酸盐）（PEDOT：PSS）被用作晶体管沟道，银（Ag）被用作卤化物选择性栅电极。最后，使用Zn-MnO ₂ -ZnCl ₂为纸OECT和车载混合电路供电基于打印的纸张的细胞和生物传感器的朝向氯之间进行区分的适用性^-临床患有囊性纤维化的诊断相关联的浓度评价为概念的证明。这项工作演示了一种简单的生物传感系统，可以在法拉第操作模式下工作，而无需实施选择性离子载体膜，并且结合了可回收性，生物降解性和生态友好性等方面。