Background Apolipoprotein A1 and B and their ratio are considered a better biomarker for cardiovascular diseases than a lipid profile, but this previous finding is not proved to cerebrovascular ischemic diseases. The aim of this study is to assess the relation between apolipoprotien A1 and B and their ratio to intra- and extracranial carotid atherosclerosis in patients with ischemic acute stroke. Methods 90 Egyptian patients with acute ischemic stroke are included in the study, and they have been classified into 3 groups: group 1 includes 30 patients with intracranial stenosis, group 2 includes 30 patients with extracranial arterial stenosis, and group 3 includes 30 patients with non-arterial stenosis. Patients were subjected to clinical assessment, routine laboratory measures, and Color-Coded Duplex Sonography for extracranial and intracranial arteries. The measurement of serum levels of apolipoproteins A1 and B was done using enzyme-linked immuno-sorbent assay (ELISA). Results A statistically significant difference was found between patient groups as regards the frequency of abnormal serum LDL-cholesterol ( p = 0.04), being elevated in patients with extracranial stenosis ( p = 0.01). There was a significant difference between patients groups as regards the frequency of abnormal serum HDL-cholesterol ( p = 0.02), being lower in patients with extracranial stenosis. High Apo B/A1 ratio was an independent risk factor for intracranial arterial stenosis ( p = 0.045). An abnormal elevation of serum LDL cholesterol was an independent risk factor of extracranial arterial stenosis ( p = 0.021). Conclusion Apo B/A1 ratio is an independent risk factor for intracranial arterial stenosis, while serum LDL cholesterol is an independent risk factor for extracranial arterial stenosis. Apo B/A1 ratio and serum LDL cholesterol are reliable serum biomarkers for cranial arterial stenosis in acute ischemic stroke patients.

中文翻译：

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急性缺血性脑卒中颅内和颅外动脉狭窄患者的载脂蛋白 A1 和 B 及其比值：一项埃及研究

背景 载脂蛋白 A1 和 B 及其比率被认为是比血脂谱更好的心血管疾病生物标志物，但先前的这一发现并未被证明是脑血管缺血性疾病。本研究的目的是评估载脂蛋白 A1 和 B 之间的关系以及它们与缺血性急性卒中患者颅内和颅外颈动脉粥样硬化的比率。方法 90例埃及急性缺血性脑卒中患者纳入研究，分为3组：第1组颅内狭窄30例，第2组颅外动脉狭窄30例，第3组非颅内动脉狭窄30例。 - 动脉狭窄。对患者进行临床评估、常规实验室检查、和用于颅外和颅内动脉的彩色编码双工超声检查。使用酶联免疫吸附测定 (ELISA) 测量血清载脂蛋白 A1 和 B 水平。结果发现患者组间血清LDL-胆固醇异常的频率（p=0.04）存在统计学显着差异，颅外狭窄患者升高（p=0.01）。在异常血清 HDL-胆固醇的频率方面，患者组之间存在显着差异（p = 0.02），颅外狭窄患者较低。高 Apo B/A1 比值是颅内动脉狭窄的独立危险因素 (p = 0.045)。血清 LDL 胆固醇异常升高是颅外动脉狭窄的独立危险因素 (p = 0.021)。结论 Apo B/A1比值是颅内动脉狭窄的独立危险因素，而血清LDL胆固醇是颅外动脉狭窄的独立危险因素。Apo B/A1 比值和血清 LDL 胆固醇是急性缺血性卒中患者颅动脉狭窄的可靠血清生物标志物。