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Most promising solid dispersion technique of oral dispersible tablet
Beni-Suef University Journal of Basic and Applied Sciences ( IF 2.5 ) Pub Date : 2020-12-01 , DOI: 10.1186/s43088-020-00086-4
Vikrant K. Nikam , Shubham K. Shete , Jyoti P. Khapare

The most common problem about conventional dosage form is dysphagia (difficulty in swallowing). So, we design a new approach in a conventional dosage form which is oral dispersible tablet. Oral dispersible tablet is also called as mouth dissolving tablet, fast dissolving tablet, or oral disintegrating tablet. Oral dispersible tablet has advantage as it quickly disintegrates into saliva when it is put on the tongue. The faster the drug disintegrates or is dissolved, the faster the absorption and the quicker the therapeutic effect of drug will be attained. This review article focuses on the progress in methods of manufacturing and various latest technologies involved in the development of oral disintegrating tablet. The solid dispersion technique is one of the novel techniques to manufacturing the oral dispersible tablet. Solid dispersion is basically a drug polymer two component system. This review article focuses on advantages, disadvantages, materials used as carrier for solid dispersions, methods of preparation of solid dispersion, classification of solid dispersion, promising drugs that can be incorporated into oral disintegrating tablet by solid dispersion techniques, and recent research in solid dispersion technique using polymers as carriers.

中文翻译:

最有前途的口服分散片固体分散技术

常规剂型最常见的问题是吞咽困难(吞咽困难)。因此,我们在传统剂型中设计了一种新方法,即口服分散片。口腔分散片又称口溶片、速溶片或口腔崩解片。口服分散片的优势在于,当它放在舌头上时,它会迅速分解成唾液。药物崩解或溶解越快,吸收越快,达到药物治疗效果的速度也就越快。这篇综述文章重点介绍了口腔崩解片开发中涉及的制造方法和各种最新技术的进展。固体分散技术是制备口服分散片的新技术之一。固体分散体基本上是一种药物聚合物双组分体系。这篇综述文章重点介绍了固体分散体的优点、缺点、用作载体的材料、固体分散体的制备方法、固体分散体的分类、可以通过固体分散技术掺入口腔崩解片的有前景的药物,以及固体分散体的最新研究以聚合物为载体的技术。
更新日期:2020-12-01
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