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Population genomics of East Asian ethnic groups
Hereditas ( IF 2.1 ) Pub Date : 2020-12-01 , DOI: 10.1186/s41065-020-00162-w Ziqing Pan 1 , Shuhua Xu 1, 2, 3, 4
Hereditas ( IF 2.1 ) Pub Date : 2020-12-01 , DOI: 10.1186/s41065-020-00162-w Ziqing Pan 1 , Shuhua Xu 1, 2, 3, 4
Affiliation
East Asia constitutes one-fifth of the global population and exhibits substantial genetic diversity. However, genetic investigations on populations in this region have been largely under-represented compared with European populations. Nonetheless, the last decade has seen considerable efforts and progress in genome-wide genotyping and whole-genome sequencing of the East-Asian ethnic groups. Here, we review the recent studies in terms of ancestral origin, population relationship, genetic differentiation, and admixture of major East- Asian groups, such as the Chinese, Korean, and Japanese populations. We mainly focus on insights from the whole-genome sequence data and also include the recent progress based on mitochondrial DNA (mtDNA) and Y chromosome data. We further discuss the evolutionary forces driving genetic diversity in East-Asian populations, and provide our perspectives for future directions on population genetics studies, particularly on underrepresented indigenous groups in East Asia.
更新日期：2020-12-01
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