New platforms are enabling radiochemistry to be carried out in tiny, microliter-scale volumes, and this capability has enormous benefits for the production of radiopharmaceuticals. These droplet-based technologies can achieve comparable or better yields compared to conventional methods, but with vastly reduced reagent consumption, shorter synthesis time, higher molar activity (even for low activity batches), faster purification, and ultra-compact system size. We review here the state of the art of this emerging direction, summarize the radiotracers and prosthetic groups that have been synthesized in droplet format, describe recent achievements in scaling up activity levels, and discuss advantages and limitations and the future outlook of these innovative devices.

新平台使放射化学能够在微小、微升规模的体积下进行，这种能力对放射性药物的生产具有巨大的好处。与传统方法相比，这些基于液滴的技术可以实现相当或更好的产量，但试剂消耗大大减少，合成时间更短，摩尔活性更高（即使对于低活性批次），纯化速度更快，系统尺寸超紧凑。我们在此回顾这一新兴方向的最新技术，总结以液滴形式合成的放射性示踪剂和假体基团，描述在扩大活性水平方面的最新成就，并讨论这些创新设备的优点和局限性以及未来前景。