Copeptin is a hypothalamic stress hormone that is synthesized in the hypothalamus together with Arginine-vasopressin and circulated from the neurohypophysis in equimolar amounts and can indicate the individual stress level. The aim of this study was to investigate the plasma copeptin level for childhood migraine headache. In this study, total oxidant status (TOS); total antioxidant status (TAS); oxidative stress index (OSI); and copeptin were measured in the plasma samples of 61 migraine patients and 60 matched healthy participants. The median plasma copeptin levels in the patients group and control group were 298.25 and 194.35 pg/mL, respectively. Copeptin levels were significantly higher in migraine patients than in the healthy control group. The specificity and sensitivity of copeptin for 249.5 pg/dL cut off value predicting diagnosis of migraine were 67% and 64%, respectively. In addition, TOS and OSI levels were found to be higher and TAS levels were significantly lower in patients with migraine than healthy controls. Plasma copeptin levels are thought to increase in cases of childhood migraine secondary to increased oxidative stress. In the diagnosis of childhood migraine cases, it can be used together with oxidative stress biomarkers such as TAS, TOS and OSI as a complementary parameter.

和肽素是一种下丘脑应激激素，与精氨酸-加压素一起在下丘脑合成，从神经垂体以等摩尔量循环，可以指示个体的应激水平。本研究的目的是调查儿童偏头痛的血浆和肽素水平。在这项研究中，总氧化状态（TOS）；总抗氧化状态（TAS）；氧化应激指数（OSI）；和肽素在 61 名偏头痛患者和 60 名匹配的健康参与者的血浆样本中进行了测量。患者组和对照组的中位血浆和肽素水平分别为 298.25 和 194.35 pg/mL。偏头痛患者的和肽素水平显着高于健康对照组。和肽素对 249 的特异性和敏感性。5 pg/dL 预测偏头痛诊断的临界值分别为 67% 和 64%。此外，偏头痛患者的 TOS 和 OSI 水平高于健康对照组，而 TAS 水平显着低于健康对照组。在继发于氧化应激增加的儿童偏头痛病例中，血浆和肽素水平被认为会增加。在儿童偏头痛病例的诊断中，它可以与氧化应激生物标志物（如 TAS、TOS 和 OSI）一起用作补充参数。