Objective. To study the clinical manifestations, magnetic resonance imaging (MRI) findings, and prognosis of delayed encephalopathy after carbon monoxide poisoning (DEACMP). Methods. The medical records of 20 patients with DEACMP were retrospectively reviewed. All the patients received hyperbaric oxygen treatment and other treatments as necessary. Results. The patients had diverse clinical manifestations, including memory deficits, personality changes, cognitive or executive function deficits, mood disorders, Parkinsonism, dystonia or other motor impairments, and akinetic mutism. MRI revealed lesions in the bilateral cerebral white matter and/or basal ganglia. Except for the pathologically confirmed DEACMP, epileptic seizure, hemiplegia, and vegetative state, the remaining symptoms had been improved, especially the cognitive impairment, which had been decreased from 95% to 25% and psychiatric symptoms also decreased from 95% to 55% at the 6-month follow-up. Conclusions. The prognosis of patients with DEACMP was poor, and they had a relatively severe disability. The early use of hyperbaric oxygen is of great significance to improve clinical efficacy and get a better prognosis.

中文翻译：

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急性一氧化碳中毒后迟发性脑病患者的临床及影像学预后

客观。研究一氧化碳中毒（DEACMP）后迟发性脑病的临床表现、磁共振成像（MRI）表现及预后。方法。对20例DEACMP患者的病历进行回顾性分析。所有患者均接受了高压氧治疗及必要时的其他治疗。结果. 患者有多种临床表现，包括记忆障碍、人格改变、认知或执行功能障碍、情绪障碍、帕金森症、肌张力障碍或其他运动障碍，以及运动性缄默症。MRI 显示双侧大脑白质和/或基底节的病变。除病理证实的DEACMP、癫痫发作、偏瘫和植物人外，其余症状均有所改善，尤其是认知障碍从95%下降到25%，精神症状也从95%下降到55%。 6个月的随访。结论. DEACMP患者预后较差，残疾程度较重。早期使用高压氧对提高临床疗效、获得更好的预后具有重要意义。