Abstract Background We aimed to evaluate the association between mean platelet volume, platelet distribution width (PDW), platelet count (PC) and plateletcrit (PCT), and the presence of sudden sensorineural hearing loss (SSNHL) and treatment response. In the literature, there is no study that investigates the platelet functions in diabetic patients with SSNHL. Methods The patients were retrospectively assigned into Group 1 (68 diabetic patients with SSNHL), Group 2 (63 nondiabetic patients with SSNHL) and Group 3 (64 healthy controls). Results PC was not significantly different between the groups (p > 0.05). MPV, PDW and PCT values were significantly higher in Group 1 as compared to Groups 2 and 3 (p < 0.05). Platelet parameters were not significantly different between the patients who were responsive and nonresponsive to the treatment. Therefore, the platelet parameters did not affect prognosis significantly in this study samples (p > 0.05). Conclusions This study showed that platelet parameters did not have a significant effect as a prognostic and predictive value in diabetic and nondiabetic patients with SSNHL. Further studies with more homogenous and larger study groups investigating the platelet parameters are needed to demonstrate microvascular damage and vascular alterations induced by diabetes mellitus.

中文翻译：

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血小板参数对突发感音神经性听力损失的糖尿病和非糖尿病患者的预后和预测价值

摘要 背景 我们的目的是评估平均血小板体积、血小板分布宽度 (PDW)、血小板计数 (PC) 和血小板压积 (PCT) 以及突发感音神经性听力损失 (SSNHL) 和治疗反应之间的关系。文献中尚无研究探讨糖尿病伴 SSNHL 患者的血小板功能。方法将患者回顾性地分为第1组（68名患有SSNHL的糖尿病患者）、第2组（63名患有SSNHL的非糖尿病患者）和第3组（64名健康对照）。结果各组间 PC 没有显着差异 (p > 0.05)。与第 2 组和第 3 组相比，第 1 组的 MPV、PDW 和 PCT 值显着更高 (p < 0.05)。对治疗有反应和无反应的患者之间的血小板参数没有显着差异。因此，本研究样本中血小板参数对预后没有显着影响（p > 0.05）。结论 本研究表明，血小板参数对于患有 SSNHL 的糖尿病和非糖尿病患者的预后和预测价值没有显着影响。需要对血小板参数进行更同质和更大的研究小组的进一步研究，以证明糖尿病引起的微血管损伤和血管改变。