Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets,Journal of Biophotonics

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Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2020-12-08 , DOI: 10.1002/jbio.202000366
Chong Huang ₁ , Siavash Mazdeyasna ₁ , Mehrana Mohtasebi ₁ , Kathryn E Saatman ₂ , Qiang Cheng ₃ , Guoqiang Yu ₁ , Lei Chen ₂

Affiliation

We adapted and tested an innovative noncontact speckle contrast diffuse correlation tomography (scDCT) system for 3D imaging of cerebral blood flow (CBF) variations in perinatal disease models utilizing neonatal piglets, which closely resemble human neonates. CBF variations were concurrently measured by the scDCT and an established diffuse correlation spectroscopy (DCS) during global ischemia, intraventricular hemorrhage, and asphyxia; significant correlations were observed. Moreover, CBF variations associated reasonably with vital pathophysiological changes. In contrast to DCS measurements of mixed signals from local scalp, skull and brain, scDCT generates 3D images of CBF distributions at prescribed depths within the head, thus enabling specific determination of regional cerebral ischemia. With further optimization and validation in animals and human neonates, scDCT has the potential to be a noninvasive imaging tool for both basic neuroscience research in laboratories and clinical applications in neonatal intensive care units.

中文翻译：

新生仔猪围产期疾病模型脑血流散斑对比弥散相关断层扫描

我们采用并测试了一种创新的非接触式散斑对比漫相关断层扫描 (scDCT) 系统，利用与人类新生儿非常相似的新生仔猪，对围产期疾病模型中的脑血流 (CBF) 变化进行 3D 成像。在全身缺血、脑室内出血和窒息期间，通过 scDCT 和已建立的弥散相关光谱 (DCS) 同时测量 CBF 变化；观察到显着的相关性。此外，CBF 变化与重要的病理生理变化合理相关。与 DCS 测量局部头皮、颅骨和大脑的混合信号不同，scDCT 可以生成头部指定深度处 CBF 分布的 3D 图像，从而能够具体确定局部脑缺血情况。随着在动物和人类新生儿中的进一步优化和验证，scDCT 有潜力成为实验室基础神经科学研究和新生儿重症监护病房临床应用的无创成像工具。

更新日期：2020-12-08

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