Myocardial remodelling is a common phenomenon in cardiovascular diseases, which threaten human health and the quality of life. Due to the lack of effective early diagnosis and treatment methods, the molecular mechanism of myocardial remodelling should be explored in depth. In this study, we observed the high expression of MBNL1 in cardiac tissue and peripheral blood of an isoproterenol (ISO)‐induced cardiac hypertrophy mouse model. MBNL1 promoted ISO‐induced cardiac hypertrophy and fibrosis by stabilizing Myocardin mRNA in vivo and in vitro. Meanwhile, an increase in MBNL1 may induce the apoptosis of cardiomyocytes treated with ISO via TNF‐α signalling. Interestingly, MBNL1 can be activated by p300 in cardiomyocytes treated with ISO. At last, Myocardin can reverse activate the expression of MBNL1. These results suggest that MBNL1 may be a potential target for the early diagnosis and clinical treatment of myocardial remodelling.

中文翻译：

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MBNL1 调节异丙肾上腺素诱导的体外和体内心肌重塑


心肌重塑是心血管疾病的常见现象，威胁人类健康和生活质量。由于缺乏有效的早期诊断和治疗方法，心肌重塑的分子机制值得深入探讨。在这项研究中，我们观察到MBNL1在异丙肾上腺素（ISO）诱导的心脏肥大小鼠模型的心脏组织和外周血中高表达。 MBNL1 通过在体内和体外稳定心肌素 mRNA 来促进 ISO 诱导的心脏肥大和纤维化。同时，MBNL1 的增加可能通过 TNF-α 信号传导诱导 ISO 处理的心肌细胞凋亡。有趣的是，在用 ISO 处理的心肌细胞中，MBNL1 可以被 p300 激活。最后，Myocardin可以逆转激活MBNL1的表达。这些结果表明MBNL1可能成为心肌重构早期诊断和临床治疗的潜在靶点。