Structural abnormalities of cingulate cortex in patients with first‐episode drug‐naïve schizophrenia comorbid with depressive symptoms,Human Brain Mapping

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Structural abnormalities of cingulate cortex in patients with first‐episode drug‐naïve schizophrenia comorbid with depressive symptoms
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-12-09 , DOI: 10.1002/hbm.25315
Gao-Xia Wei _{1,

2,

3} , Likun Ge _{1,

3} , Li-Zhen Chen _{1,

3} , Bo Cao ₄ , Xiangyang Zhang ₁

Affiliation

Depressive symptoms are common in patients with first‐episode psychosis. However, the neural mechanisms underlying the comorbid depression in schizophrenia are still unknown. The main purpose of this study was to characterize the structural abnormalities of first‐episodes drug‐naïve (FEDN) schizophrenia comorbid with depression by utilizing both volume‐based and surface‐based morphometric measurements. Forty‐two patients with FEDN schizophrenia and 29 healthy controls were recruited. The 24‐item Hamilton Depression Rating Scale (HAMD‐24) was administrated to divide all patients into depressive patients (DP) and non‐depressive patients (NDP). Compared with NDP, DP had a significantly larger volume and surface area in the left isthmus cingulate cortex and also had a greater volume in the left posterior cingulate cortex. Correlation analysis showed that HAMD total score was positively correlated with the surface area of the left isthmus cingulate and gray matter volume of the left isthmus cingulate cortex. In addition, gray matter volume of the left isthmus cingulate was also correlated with the PANSS general psychopathology or total score. The findings suggest that prominent structural abnormalities of gray matter are mainly concentrated on the cingulate cortex in FEDN schizophrenia patients comorbid with depression, which may contribute to depressive symptoms and psychopathological symptoms.

中文翻译：

首发药物初治精神分裂症合并抑郁症状的扣带回皮层结构异常

抑郁症状在首发精神病患者中很常见。然而，精神分裂症共病抑郁症的神经机制尚不清楚。本研究的主要目的是通过利用基于体积和基于表面的形态测量测量来表征首发药物初治 (FEDN) 精神分裂症合并抑郁症的结构异常。招募了 42 名 FEDN 精神分裂症患者和 29 名健康对照者。采用 24 项汉密尔顿抑郁量表 (HAMD-24) 将所有患者分为抑郁患者 (DP) 和非抑郁患者 (NDP)。与NDP相比，DP在左峡部扣带回皮层的体积和表面积明显更大，在左后扣带回皮层的体积也更大。相关性分析表明，HAMD总分与左峡部扣带回表面积和左峡部扣带回皮层灰质体积呈正相关。此外，左峡部扣带回的灰质体积也与 PANSS 一般精神病理学或总分相关。研究结果表明，在 FEDN 精神分裂症合并抑郁症的患者中，灰质的显着结构异常主要集中在扣带回皮层，这可能导致抑郁症状和心理病理症状。左峡部扣带回的灰质体积也与 PANSS 一般精神病理学或总分相关。研究结果表明，在 FEDN 精神分裂症合并抑郁症的患者中，灰质的显着结构异常主要集中在扣带回皮层，这可能导致抑郁症状和心理病理症状。左峡部扣带回的灰质体积也与 PANSS 一般精神病理学或总分相关。研究结果表明，在 FEDN 精神分裂症合并抑郁症的患者中，灰质的显着结构异常主要集中在扣带回皮层，这可能导致抑郁症状和心理病理症状。

更新日期：2020-12-09

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