Neural stem cell pools in the vertebrate adult brain: Homeostasis from cell‐autonomous decisions or community rules?,BioEssays

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Neural stem cell pools in the vertebrate adult brain: Homeostasis from cell‐autonomous decisions or community rules?
BioEssays ( IF 3.2 ) Pub Date : 2020-12-09 , DOI: 10.1002/bies.202000228
Nicolas Dray ₁ , Emmanuel Than-Trong _{1,

2} , Laure Bally-Cuif ₁

Affiliation

Adult stem cell populations must coordinate their own maintenance with the generation of differentiated cell types to sustain organ physiology, in a spatially controlled manner and over long periods. Quantitative analyses of clonal dynamics have revealed that, in epithelia, homeostasis is achieved at the population rather than at the single stem cell level, suggesting that feedback mechanisms coordinate stem cell maintenance and progeny generation. In the central nervous system, however, little is known of the possible community processes underlying neural stem cell maintenance. Recent work, in part based on intravital imaging made possible in the adult zebrafish, conclusively highlights that homeostasis in neural stem cell pools may rely on population asymmetry and long‐term spatiotemporal coordination of neural stem cell states and fates. These results suggest that neural stem cell assemblies in the vertebrate brain behave as self‐organized systems, such that the stem cells themselves generate their own intrinsic niche.

中文翻译：

脊椎动物成年大脑中的神经干细胞池：来自细胞自主决定或社区规则的稳态？

成体干细胞群必须协调其自身的维持与分化细胞类型的产生，以空间控制的方式和长期维持器官生理机能。克隆动力学的定量分析表明，在上皮细胞中，稳态是在群体而不是单个干细胞水平上实现的，这表明反馈机制协调干细胞维持和后代的产生。然而，在中枢神经系统中，人们对神经干细胞维持潜在的群落过程知之甚少。最近的工作部分基于在成年斑马鱼中实现的活体成像，最终强调神经干细胞库中的稳态可能依赖于种群不对称性和神经干细胞状态和命运的长期时空协调。

更新日期：2020-12-09

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