This study aimed to evaluate the effects of leptin, ghrelin and neuropeptide-Y on the development of nonconvulsive seizure activity and their role on combating oxidative stress and cytokines produced by the systemic immune response in the WAG/Rij rat model for genetic absence epilepsy. Current study showed that all three peptides aggravated spike wave discharges activity and affected the oxidative stress in WAG/Rij rats without any significant changes in the levels of IL-1β, IL-6 and TNF-α except leptin that only induced an increment in the concentration of IL-1β. Our results support the modulatory role of these endogenous peptides on absence epilepsy.

中文翻译：

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瘦素、生长素释放肽和神经肽 y 对 WAG/Rij 遗传性失神癫痫大鼠棘波放电活性和某些生化参数的影响

本研究旨在评估瘦素、生长素释放肽和神经肽-Y 对非惊厥性癫痫发作发展的影响及其在 WAG/Rij 遗传性失神癫痫大鼠模型中对抗全身免疫反应产生的氧化应激和细胞因子的作用。目前的研究表明，除了瘦素仅诱导增加的外，所有三种肽都加剧了 WAG/Rij 大鼠的棘波放电活动并影响了氧化应激，IL-1β、IL-6 和 TNF-α 的水平没有任何显着变化。 IL-1β 的浓度。我们的结果支持这些内源性肽对失神癫痫的调节作用。