Orientia tsutsugamushi (OT), the causative agent of the vector-borne Scrub typhus zoonotic disease in humans, is a unique microorganism that exists in the Asia-Pacific region since a long time. In spite of its occurrence, the organism had been neglected until recent years. Humans are the accidental dead-end hosts of O. tsutsugamushi and display manifestations which are both severe and misleading. The vast antigenic diversity of OT and non-pathognomic symptoms of Scrub typhus, create hurdles in the clinical management of the disease and impede the OT-research. Many countries in the Asia-Pacific region have reported the resurgence of OT- infections and have raised concerns for its expanding distribution. This has triggered the development of advanced techniques for diagnosis and research on exploring a successful vaccine candidate to reduce the burden of the disease. Thus, the aim of this systematic review is to provide an update on the recent advances in the OT-research and highlight the key areas that have remained obscure and demand attention.

东方虫病（OT）是人类传播的媒介斑疹伤寒人畜共患病的病原体，是一种长期存在于亚太地区的独特微生物。尽管出现了这种生物，但直到近年才被忽略。人类是O虫病的偶然死胡同并显示既严重又具有误导性的表现。OT的巨大抗原多样性和斑疹伤寒的非病理学症状，在疾病的临床管理中造成障碍，并阻碍了OT研究。亚太地区的许多国家都报告了OT感染的再次流行，并对其传播范围的扩大提出了担忧。这触发了用于探索和探索成功的候选疫苗以减轻疾病负担的先进诊断和研究技术的发展。因此，本系统综述的目的是提供关于旧约研究的最新进展的最新信息，并重点介绍仍不清楚和需要关注的关键领域。