Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi and is endemic to many parts of the Asia-Pacific region. We investigated whether the genotype of O. tsutsugamushi or the DNA load would be a useful marker of disease severity in scrub typhus patients. We evaluated the clinical features, genotypes and bacterial DNA load in the blood of 118 patients, including 114 surviving and 4 non-surviving patients, admitted at Chosun University Hospital.

Four patients infected with the Pajoo, Yonchon, Youngworl and Boryong genotypes died. In the 114 survivors, 100 Boryong and 2 Taguchi genotypes were identified. The genotypes involved showed significant differences between the surviving and non-surviving patients (p<0.001). The median number of O. tsutsugamushi DNA copies was 78 copies /μL (range 3,960) in surviving patients, whereas 83,800 copies/μL (range 244,600) in the non-surviving patients.

We found that the genotype and DNA load in the patient's blood are useful markers of disease severity in scrub typhus.

斑疹伤寒是急性Or虫病，由东方acute虫病引起，是亚太地区许多地方的特有病。我们调查了O虫O. s基因型或DNA负载是否将是灌木斑疹伤寒患者疾病严重程度的有用标志。我们评估了朝鲜大学医院收治的118例患者的临床特征，基因型和细菌DNA负荷，包括114例存活的和4例非存活的患者。

感染Pajoo，Yonchon，Youngworl和Boryong基因型的4名患者死亡。在114名幸存者中，鉴定出100个鲍荣和2个田口基因型。所涉及的基因型在幸存者和非幸存者之间显示出显着差异（p <0.001）。中位数恙虫病东方体DNA拷贝为78份在存活患者/μL（范围3960），而在非存活者83800个拷贝/μL（范围244600）。

我们发现患者血液中的基因型和DNA负载是灌木斑疹伤寒中疾病严重程度的有用标志。