Borrelia burgdorferi sensu lato causes Lyme borreliosis in a variety of animals and humans. These atypical bacterial pathogens are maintained in a complex enzootic life cycle that primarily involves a vertebrate host and Ixodes spp. ticks. In the Northeastern United States, I. scapularis is the main vector, while wild rodents serve as the mammalian reservoir host. As B. burgdorferi is transmitted only by I. scapularis and closely related ticks, the spirochete-tick interactions are thought to be highly specific. Various borrelial and arthropod proteins that directly or indirectly contribute to the natural cycle of B. burgdorferi infection have been identified. Discrete molecular interactions between spirochetes and tick components also have been discovered, which often play critical roles in pathogen persistence and transmission by the arthropod vector. This review will focus on the past discoveries and future challenges that are relevant to our understanding of the molecular interactions between B. burgdorferi and Ixodes ticks. This information will not only impact scientific advancements in the research of tick- transmitted infections but will also contribute to the development of novel preventive measures that interfere with the B. burgdorferi life cycle.

中文翻译：

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蜱虫和莱姆病螺旋体之间的相互作用。


伯氏疏螺旋体在多种动物和人类中引起莱姆疏螺旋体病。这些非典型细菌病原体维持在复杂的地方性动物生命周期中，主要涉及脊椎动物宿主和硬蜱属。滴答声。在美国东北部，肩胛 I. scapularis是主要媒介，而野生啮齿动物是哺乳动物的储存宿主。由于伯氏疏螺旋体仅由肩胛疏螺旋体和密切相关的蜱传播，因此螺旋体与蜱的相互作用被认为是高度特异性的。已鉴定出直接或间接促进伯氏疏螺旋体感染自然循环的各种疏螺旋体和节肢动物蛋白。螺旋体和蜱成分之间的离散分子相互作用也已被发现，这通常在病原体的持久性和节肢动物媒介的传播中发挥着关键作用。本综述将重点关注与我们对伯氏疏螺旋体和硬蜱之间分子相互作用的理解相关的过去的发现和未来的挑战。这些信息不仅会影响蜱传播感染研究的科学进步，而且还将有助于开发干扰伯氏疏螺旋体生命周期的新型预防措施。