Owing to the wide applications and significance of phloroglucide analogues in organic synthesis, pharmacology and industry, there is considerable interest in the synthesis of these compounds. Nevertheless, there are few methods for preparation of these compounds. Here we reported a simple, clean, and highly efficient procedure for the green synthesis of tricyclic polyhydroxyl aromatic compounds. Microwave-assisted alkylation reaction between 4-substituted-2, 6-bis(chloromethyl)phenols and various phenol derivatives, in the presence of zinc oxide (ZnO) in 1-butyl-3-methylimidazolium hexaflourophosphate ([Bmim]PF₆), affords the title compounds in short duration with high yields. We have synthesized 18 derivatives of the title compounds 3a-3r by this procedure. Chemical structures of all synthesized compounds have been confirmed by spectrophotometric methods such as IR, NMR and mass spectroscopy. Some of the synthesized compounds have been screened for their antimicrobial activities. Antifungal and antibacterial activities have been evaluated against different species of microorganisms including gram positive and gram negative bacteria as well as fungi. Broth microdilution method as recommended by Clinical and Laboratory Standard Institute has been used for this purpose. The results show compounds 3i, 3k and 3m have the best antibacterial and antifungal activity against most of the examined species. Compounds 3b, 3f, 3o, 3p and 3q also show good activity against some species.

中文翻译：

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微波辐射下离子液体中的ZnO：一种新型的合成抗微生物的间苯二甲酰胺衍生物的介质

由于间苯三酚类似物在有机合成，药理学和工业中的广泛应用和重要性，因此对这些化合物的合成有相当大的兴趣。然而，几乎没有制备这些化合物的方法。在这里，我们报道了一种简单，清洁，高效的绿色合成三环多羟基芳香族化合物的方法。在1-丁基-3-甲基咪唑鎓六氟磷酸盐（[Bmim] PF ₆）中，在氧化锌（ZnO）存在下，4-取代-2,6-双（氯甲基）酚与各种酚衍生物之间的微波辅助烷基化反应，在短时间内以高收率得到标题化合物。我们已经合成了18种标题化合物3a-3r的衍生物通过此过程。所有合成化合物的化学结构已通过分光光度法（例如IR，NMR和质谱法）确认。已经筛选了一些合成的化合物的抗微生物活性。已经评估了针对不同种类的微生物（包括革兰氏阳性和革兰氏阴性细菌以及真菌）的抗真菌和抗菌活性。为此，使用了临床和实验室标准协会推荐的肉汤微量稀释方法。结果表明，化合物3i，3k和3m对大多数受检物种具有最佳的抗菌和抗真菌活性。化合物3b，3f，3o，3p和3q对某些物种也表现出良好的活性。