As we know that, Oxadiazole or furadi azole ring containing derivatives are an important class of heterocyclic compounds. A heterocyclic five-membered ring that possesses two carbons, one oxygen atom, two nitrogen atoms, and two double bonds is known as oxadiazole. They are derived from furan by the replacement of two methylene groups (= CH) with two nitrogen (-N =) atoms. The aromaticity was reduced with the replacement of these groups in the furan ring to such an extent that it shows conjugated diene character. Four different known isomers of oxadiazole were existed such as 1,2,4-oxadiazole, 1,2,3-oxadiazole, 1,2,5-oxadiazole & 1,3,4-oxadiazole. Among them, 1,3,4-oxadiazoles & 1,2,4-oxadiazoles are better known and more widely studied by the researchers due to their broad range of chemical and biological properties. 1,3,4-oxadiazoles have become important synthons in the development of new drugs. The derivatives of the oxadiazole nucleus (1,3,4-oxadiazoles) show various biological activities such as antibacterial, anti-mycobacterial, antitumor, anti-viral and antioxidant activity, etc. as reported in the literature. There are different examples of commercially available drugs which consist of 1,3,4-oxadiazole ring such as nitrofuran derivative (Furamizole) which has strong antibacterial activity, Raltegravir as an antiviral drug and Nesapidil drug is used in anti-arrhythmic therapy. This present review summarized some pharmacological activities and various kinds of synthetic routes for 2, 5-disubstituted 1,3,4-oxadiazole, and their derived products.

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含有恶二唑或呋喃二唑的化合物的治疗潜力

众所周知，含有恶二唑或呋喃二唑环的衍生物是一类重要的杂环化合物。具有两个碳，一个氧原子，两个氮原子和两个双键的杂环五元环称为恶二唑。它们是通过将两个亚甲基（= CH）替换为两个氮（-N =）原子而从呋喃衍生而来的。呋喃环中这些基团的取代使芳香性降低到显示共轭二烯特征的程度。存在四种不同的恶二唑异构体，例如1,2,4-恶二唑，1,2,3-恶二唑，1,2,5-恶二唑和1,3,4-恶二唑。其中，1,3,4-恶二唑和1,2,4-恶二唑因其广泛的化学和生物学特性而被研究者广泛研究。1,3，4-恶二唑已成为新药开发中的重要合成子。恶二唑核的衍生物（1,3,4-恶二唑）显示出各种生物学活性，例如抗菌，抗分枝杆菌，抗肿瘤，抗病毒和抗氧化活性等。存在由1,3,4-恶二唑环组成的市售药物的不同实例，例如具有强抗菌活性的硝基呋喃衍生物（呋喃唑），Raltegravir作为抗病毒药和Nesapidil药物用于抗心律不齐治疗。这篇综述总结了2，5-二取代的1,3,4-恶二唑及其衍生产物的一些药理活性和各种合成途径。如文献所报道的，4-恶二唑）显示出各种生物学活性，例如抗菌，抗分枝杆菌，抗肿瘤，抗病毒和抗氧化活性等。存在由1,3,4-恶二唑环组成的市售药物的不同实例，例如具有强抗菌活性的硝基呋喃衍生物（呋喃唑），Raltegravir作为抗病毒药和Nesapidil药物用于抗心律不齐治疗。这篇综述总结了2，5-二取代的1,3,4-恶二唑及其衍生产物的一些药理活性和各种合成途径。如文献所报道的，4-恶二唑）显示出各种生物学活性，例如抗菌，抗分枝杆菌，抗肿瘤，抗病毒和抗氧化活性等。存在由1,3,4-恶二唑环组成的市售药物的不同实例，例如具有强抗菌活性的硝基呋喃衍生物（呋喃唑），Raltegravir作为抗病毒药和Nesapidil药物用于抗心律不齐治疗。这篇综述总结了2，5-二取代的1,3,4-恶二唑及其衍生产物的一些药理活性和各种合成途径。存在由1,3,4-恶二唑环组成的市售药物的不同实例，例如具有强抗菌活性的硝基呋喃衍生物（呋喃唑），Raltegravir作为抗病毒药和Nesapidil药物用于抗心律不齐治疗。这篇综述总结了2，5-二取代的1,3,4-恶二唑及其衍生产物的一些药理活性和各种合成途径。存在由1,3,4-恶二唑环组成的市售药物的不同实例，例如具有强抗菌活性的硝基呋喃衍生物（呋喃唑），Raltegravir作为抗病毒药和Nesapidil药物用于抗心律不齐治疗。这篇综述总结了2，5-二取代的1,3,4-恶二唑及其衍生产物的一些药理活性和各种合成途径。