Background: Previous evidence has suggested that norepinephrine transporter (NET) gene (solute carrier family 6, member 2 [SLC6A2]) polymorphisms are involved in antidepressant response. Specifically, the polymorphism T-182C (rs2242446) located in the promoter region of SLC6A2 has been found to be associated with antidepressant response in multiple ethnic backgrounds. However, the results are inconsistent. Moreover, few studies have focused on how this T-182C polymorphism might regulate SLC6A2 promoter function.

中文翻译：

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T-182C多态性增强去甲肾上腺素转运蛋白基因的启动子活性，但可能与抗抑郁反应无关

背景：以前的证据表明，去甲肾上腺素转运蛋白（ NET）基因（溶质载体家族6，成员2 [ SLC6A2 ]）多态性与抗抑郁反应有关。具体而言，位于启动子区多态性T-182C（rs2242446） SLC6A2已发现与在多个种族背景抗抑郁响应相关联。但是，结果不一致。此外，很少有研究集中于这种T- 182C多态性如何调节SLC6A2启动子功能。