当前位置：
X-MOL 学术
›
Ann. Indian Acad. Neurol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Brain MRI in Epstein–Barr Virus Meningoencephalitis in Children
Annals of Indian Academy of Neurology ( IF 1.7 ) Pub Date : 2020-09-01 , DOI: 10.4103/aian.aian_537_19 Sameer Vyas 1 , Renu Suthar 2 , Vikas Bhatia 1 , Nidhi Bhardwaj 3 , Ritu Aggarwal 4 , Pratibha Singhi 5, 6 , Sunit Singhi 5, 6
Background and Purpose: Epstein–Barr virus (EBV) meningoencephalitis can have variable and nonspecific brain magnetic resonance imaging (MRI) findings in children. This study was done with the purpose of describing brain MRI findings in children with EBV meningoencephalitis. Materials and Methods: The study included 45 pediatric patients that presented with variable neurological symptoms and were found to have EBV meningoencephalitis based on positive EBV deoxyribonucleic acid (DNA) in the cerebrospinal fluid. All these patients had undergone brain MRI. Clinical and radiological features were evaluated. Results: Fever was a presenting feature in all cases. Signs of meningitis and raised intracranial pressure (ICP) were seen in 24 (53.3%) cases, encephalopathy in 15 (33.3%), and seizures were present in 33 (73.3%). MRI was abnormal in 29 (64.4%) patients. The cortical/subcortical pattern was diagnosed in 9 (20%) cases, white matter involvement in 7 (15.5%), basal ganglia in 5 (11.1%), thalamic involvement in 4 (8.8%), brain stem involvement in 2 (6.2%), substantia nigra involvement in 2 (4.4%), and cerebellar involvement in 2 (4.4%). Diffusion restriction was present in 11 (24.4%) cases and susceptibility changes in 7 (15.5%). Meningeal enhancement was present in 10 (22.2%) cases. In addition, brain abscess and subdural effusion/empyema were present in 1 (2.2%) case each. Conclusion: Pediatric EBV meningoencephalitis has varied clinicoradiological spectrum and there is no specific MRI pattern to characterize the meningoencephalitis on imaging. Common MRI findings include cortical-subcortical involvement, white matter changes, basal ganglia, and thalamic involvement.
中文翻译：
儿童 Epstein-Barr 病毒脑膜脑炎的脑部 MRI
背景和目的：爱泼斯坦-巴尔病毒 (EBV) 脑膜脑炎在儿童中可能有可变和非特异性的脑磁共振成像 (MRI) 表现。本研究旨在描述 EBV 脑膜脑炎患儿的脑部 MRI 结果。材料和方法：该研究包括 45 名出现不同神经系统症状的儿科患者，根据脑脊液中 EBV 脱氧核糖核酸 (DNA) 阳性发现患有 EBV 脑膜脑炎。所有这些患者都接受了脑部MRI检查。评估了临床和放射学特征。结果：在所有情况下，发烧都是一个表现特征。24 例（53.3%）病例出现脑膜炎和颅内压升高（ICP），15 例（33.3%）出现脑病，33 例（73.3%）出现癫痫。29 名 (64.4%) 患者的 MRI 异常。皮层/皮层下模式被诊断出 9 例（20%），白质受累 7 例（15.5%），基底神经节 5 例（11.1%），丘脑受累 4 例（8.8%），脑干受累 2 例（6.2 %)，黑质受累 2 人 (4.4%)，小脑受累 2 人 (4.4%)。11 例 (24.4%) 病例出现扩散受限，7 例 (15.5%) 病例出现易感性变化。10 例 (22.2%) 病例出现脑膜强化。此外，脑脓肿和硬膜下积液/脓胸各1例（2.2%）。结论：小儿 EBV 脑膜脑炎具有不同的临床放射学谱，并且没有特定的 MRI 模式来表征脑膜脑炎的影像学特征。常见的 MRI 表现包括皮质-皮质下受累、白质改变、基底神经节和丘脑受累。
更新日期：2020-09-01
Annals of Indian Academy of Neurology ( IF 1.7 ) Pub Date : 2020-09-01 , DOI: 10.4103/aian.aian_537_19 Sameer Vyas 1 , Renu Suthar 2 , Vikas Bhatia 1 , Nidhi Bhardwaj 3 , Ritu Aggarwal 4 , Pratibha Singhi 5, 6 , Sunit Singhi 5, 6
Affiliation
Background and Purpose: Epstein–Barr virus (EBV) meningoencephalitis can have variable and nonspecific brain magnetic resonance imaging (MRI) findings in children. This study was done with the purpose of describing brain MRI findings in children with EBV meningoencephalitis. Materials and Methods: The study included 45 pediatric patients that presented with variable neurological symptoms and were found to have EBV meningoencephalitis based on positive EBV deoxyribonucleic acid (DNA) in the cerebrospinal fluid. All these patients had undergone brain MRI. Clinical and radiological features were evaluated. Results: Fever was a presenting feature in all cases. Signs of meningitis and raised intracranial pressure (ICP) were seen in 24 (53.3%) cases, encephalopathy in 15 (33.3%), and seizures were present in 33 (73.3%). MRI was abnormal in 29 (64.4%) patients. The cortical/subcortical pattern was diagnosed in 9 (20%) cases, white matter involvement in 7 (15.5%), basal ganglia in 5 (11.1%), thalamic involvement in 4 (8.8%), brain stem involvement in 2 (6.2%), substantia nigra involvement in 2 (4.4%), and cerebellar involvement in 2 (4.4%). Diffusion restriction was present in 11 (24.4%) cases and susceptibility changes in 7 (15.5%). Meningeal enhancement was present in 10 (22.2%) cases. In addition, brain abscess and subdural effusion/empyema were present in 1 (2.2%) case each. Conclusion: Pediatric EBV meningoencephalitis has varied clinicoradiological spectrum and there is no specific MRI pattern to characterize the meningoencephalitis on imaging. Common MRI findings include cortical-subcortical involvement, white matter changes, basal ganglia, and thalamic involvement.
中文翻译：
儿童 Epstein-Barr 病毒脑膜脑炎的脑部 MRI
背景和目的：爱泼斯坦-巴尔病毒 (EBV) 脑膜脑炎在儿童中可能有可变和非特异性的脑磁共振成像 (MRI) 表现。本研究旨在描述 EBV 脑膜脑炎患儿的脑部 MRI 结果。材料和方法：该研究包括 45 名出现不同神经系统症状的儿科患者，根据脑脊液中 EBV 脱氧核糖核酸 (DNA) 阳性发现患有 EBV 脑膜脑炎。所有这些患者都接受了脑部MRI检查。评估了临床和放射学特征。结果：在所有情况下，发烧都是一个表现特征。24 例（53.3%）病例出现脑膜炎和颅内压升高（ICP），15 例（33.3%）出现脑病，33 例（73.3%）出现癫痫。29 名 (64.4%) 患者的 MRI 异常。皮层/皮层下模式被诊断出 9 例（20%），白质受累 7 例（15.5%），基底神经节 5 例（11.1%），丘脑受累 4 例（8.8%），脑干受累 2 例（6.2 %)，黑质受累 2 人 (4.4%)，小脑受累 2 人 (4.4%)。11 例 (24.4%) 病例出现扩散受限，7 例 (15.5%) 病例出现易感性变化。10 例 (22.2%) 病例出现脑膜强化。此外，脑脓肿和硬膜下积液/脓胸各1例（2.2%）。结论：小儿 EBV 脑膜脑炎具有不同的临床放射学谱，并且没有特定的 MRI 模式来表征脑膜脑炎的影像学特征。常见的 MRI 表现包括皮质-皮质下受累、白质改变、基底神经节和丘脑受累。
京公网安备 11010802027423号