Objective: Parkinson’s disease (PD) is a neurodegenerative disorder. It has a significant impact on the quality of life of patients and their caregivers. The present study aims to study the phenomena of neuropsychiatric symptoms and their association with caregiver burden in PD. Methods: The study was conducted in 100 patients of Parkinson’s disease and their primary caregivers. The patients of PD were diagnosed on the basis of UK Brain Bank criteria; severity/staging of Parkinson’s disease was done by Movement Disorder Society - Unified Parkinson’s disease rating scale (MDS-UPDRS-III). Patients who fulfilled inclusion and exclusion criteria were recruited for the study. The neuropsychiatric evaluation was based on Neuropsychiatric Inventory-Questionnaire (NPI-Q). Caregiver burden was assessed with the Zarit Caregiver Burden Inventory (ZCBI). Results: Mean age of PD patients was 61.48 ± 6.71 years, majority of them were males (68%). Mean total NPI score of patients was 44.46 ± 5.38. Mean age of caregivers was 52.26 ± 6.80 years, majority of them were females (72%) and spouse (76%) in relation to the patient. Caregiver burden was significantly related to age of the patient, duration of illness, severity of illness, and total NPI score. Conclusion: Neuropsychiatric symptoms significantly contribute to the caregiver burden in Parkinson’s disease.


中文翻译：

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帕金森病的神经精神症状和照顾者负担


目的：帕金森病（PD）是一种神经退行性疾病。它对患者及其护理人员的生活质量产生重大影响。本研究旨在研究神经精神症状现象及其与 PD 照顾者负担的关系。方法：该研究在 100 名帕金森病患者及其主要照顾者中进行。PD患者根据UK Brain Bank标准进行诊断；帕金森病的严重程度/分期由运动障碍协会 - 统一帕金森病评定量表 (MDS-UPDRS-III) 完成。招募符合纳入和排除标准的患者进行研究。神经精神病学评估基于神经精神病学问卷调查 (NPI-Q)。看护者负担通过 Zarit 看护者负担清单 (ZCBI) 进行评估。结果：PD 患者的平均年龄为 61.48 ± 6.71 岁，其中大多数是男性（68%）。患者的平均总 NPI 评分为 44.46 ± 5.38。照顾者的平均年龄为 52.26 ± 6.80 岁，其中大多数是女性 (72%) 和与患者相关的配偶 (76%)。照顾者负担与患者年龄、病程、疾病严重程度和 NPI 总分显着相关。结论：神经精神症状显着增加了帕金森病的照顾者负担。