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Ontogeny of spontaneous recognition memory in rodents
Neurobiology of Learning and Memory ( IF 2.2 ) Pub Date : 2020-12-08 , DOI: 10.1016/j.nlm.2020.107361
Arely Cruz-Sanchez 1 , Jennifer Wilkin 2 , Maithe Arruda-Carvalho 1
Affiliation  

Spontaneous recognition memory tasks explore the whatwhere and when components of recognition memory. These tasks are widely used in rodents to assess cognitive function across the lifespan. While several neurodevelopmental and mental disorders present symptom onset in early life, very little is known about how memories are expressed in early life, and as a consequence how they may be affected in pathological conditions. In this review, we conduct an analysis of the studies examining the expression of spontaneous recognition memory in young rodents. We compiled studies using four different tasks: novel object recognition, object location, temporal order recognition and object place. First, we identify major sources of variability between early life spontaneous recognition studies and classify them for later comparison. Second, we use these classifications to explore the current knowledge on the ontogeny of each of these four spontaneous recognition memory tasks. We conclude by discussing the possible implications of the relative time of onset for each of these tasks and their respective neural correlates. In compiling this research, we hope to advance on establishing a developmental timeline for the emergence of distinct components of recognition memory, while also identifying key areas of focus for future research. Establishing the ontogenetic profile of rodent spontaneous recognition memory tasks will create a necessary blueprint for cognitive assessment in animal models of neurodevelopmental and mental disorders, a first step towards improved and earlier diagnosis as well as novel intervention strategies.



中文翻译:

啮齿动物自发识别记忆的个体发育

自发识别记忆任务探索 什么、 何地 和 何时 识别记忆的组成部分。这些任务广泛用于啮齿动物,以评估整个生命周期的认知功能。虽然一些神经发育和精神障碍在生命早期出现症状,但关于记忆在生命早期是如何表达的,以及因此它们如何在病理条件下受到影响,我们知之甚少。在这篇综述中,我们对检查年轻啮齿动物自发识别记忆表达的研究进行了分析。我们使用四种不同的任务来编译研究:新物体识别、物体定位、时间顺序识别和物体位置。首先,我们确定早期生活自发识别研究之间差异的主要来源,并将它们分类以供以后比较。第二,我们使用这些分类来探索关于这四个自发识别记忆任务中每一个的个体发育的当前知识。我们最后讨论了这些任务的相对开始时间及其各自的神经相关性的可能影响。在编制这项研究时,我们希望推进建立识别记忆不同成分出现的发展时间表,同时确定未来研究的重点领域。建立啮齿动物自发识别记忆任务的个体遗传特征将为神经发育和精神障碍动物模型的认知评估创建必要的蓝图,这是改进和早期诊断以及新干预策略的第一步。我们最后讨论了这些任务的相对开始时间及其各自的神经相关性的可能影响。在编制这项研究时,我们希望推进建立识别记忆不同成分出现的发展时间表,同时确定未来研究的重点领域。建立啮齿动物自发识别记忆任务的个体遗传特征将为神经发育和精神障碍动物模型的认知评估创建必要的蓝图,这是改进和早期诊断以及新干预策略的第一步。我们最后讨论了这些任务的相对开始时间及其各自的神经相关性的可能影响。在编制这项研究时,我们希望推进建立识别记忆不同成分出现的发展时间表,同时确定未来研究的重点领域。建立啮齿动物自发识别记忆任务的个体遗传特征将为神经发育和精神障碍动物模型的认知评估创建必要的蓝图,这是改进和早期诊断以及新干预策略的第一步。我们希望推进建立识别记忆不同成分出现的发展时间表,同时确定未来研究的重点领域。建立啮齿动物自发识别记忆任务的个体遗传特征将为神经发育和精神障碍动物模型的认知评估创建必要的蓝图,这是改进和早期诊断以及新干预策略的第一步。我们希望推进建立识别记忆不同成分出现的发展时间表,同时确定未来研究的重点领域。建立啮齿动物自发识别记忆任务的个体遗传特征将为神经发育和精神障碍动物模型的认知评估创建必要的蓝图,这是改进和早期诊断以及新干预策略的第一步。

更新日期:2020-12-18
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