Abstract

Polybrominated diphenyl ethers (PBDEs) levels in environmental matrices have generally declined following their phaseout as flame retardants. The objective of this study was to determine the absorption, distribution, metabolism, and excretion of three persistent PBDEs in laying hens and their transfer into eggs. Laying hens (n = 4 per congener) received a single oral dose of BDE-99, -153, or -209 and eggs and excreta were collected daily for 7 days, then tissues were collected and analyzed. Cumulative BDE-209 excretion was 93% of dose, and bioavailability was approximately 17%. Lesser amounts of BDE-99 (41%) and -153 (26%) were excreted with bioavailabilities of 87% and 79%, respectively. Phenolic metabolites were observed in excreta extracts from BDE-99 dosed birds. Cumulative transfers based on bioavailability of BDE-99, -153, and 209 to eggs were 17%, 34%, and 15%, respectively. Egg residues were primarily present in yolk (12.3%, 23.5%, and 2.1% of the total dose for BDE-99, 153, and 209, respectively). Adipose, skin, ova, and intestine contained the highest levels of radioactive tissue residues. These studies demonstrate movement of PBDE residues into edible tissues and eggs of laying hens.

摘要

在逐步淘汰其作为阻燃剂后，环境基质中的多溴二苯醚（PBDEs）水平普遍下降。这项研究的目的是确定蛋鸡中三种持久性多溴二苯醚的吸收，分布，代谢和排泄及其向蛋中的转移。产蛋鸡（每只同类鸡n = 4）接受单次口服BDE-99，-153或-209剂量，每天收集鸡蛋和排泄物7天，然后收集并分析组织。BDE-209的累积排泄量为剂量的93％，生物利用度约为17％。排泄出较少量的BDE-99（41％）和-153（26％），生物利用度分别为87％和79％。在BDE-99剂量的家禽的排泄物提取物中观察到了酚类代谢物。根据BDE-99，-153，和209对鸡蛋的分别为17％，34％和15％。鸡蛋残留物主要存在于蛋黄中（BDE-99、153和209分别占总剂量的12.3％，23.5％和2.1％）。脂肪，皮肤，卵和肠道中放射性组织残留量最高。这些研究证明了多溴二苯醚残留物向蛋鸡的食用组织和卵中移动。