The development of pneumococcal conjugate vaccines has substantially decreased the incidence of invasive pneumococcal diseases. However, the incidence of bacteremia due to nonvaccine serotypes has increased. Therefore, it is important to recognize the symptoms and complications of pneumococcal infection to expedite diagnosis. Herein, we report the case of a 22-month-old patient diagnosed with pneumococcal bacteremia who presented with cholestatic jaundice and fever without any other signs of systemic sepsis. The patient's condition improved soon after antibacterial therapy. Other causes of jaundice were possibly ruled out based on the screening test for viral hepatitis, and there were no abnormal findings on abdominal ultrasonography. Therefore, the present case suggests that cholestatic jaundice could be a manifestation of pneumococcal bacteremia.

肺炎球菌结合疫苗的开发已大大降低了侵袭性肺炎球菌疾病的发病率。但是，由于非疫苗血清型引起的菌血症发生率增加了。因此，重要的是认识肺炎球菌感染的症状和并发症以加快诊断。本文中，我们报告了22例诊断为肺炎球菌菌血症的患者，该患者出现胆汁淤积性黄疸和发烧，而没有任何其他系统性败血症迹象。抗菌治疗后患者的病情很快好转。根据病毒性肝炎的筛查结果，可能排除了其他黄疸的病因，腹部超声检查未发现异常。因此，