Autism spectrum disorder (ASD) and food allergy (FA) are global public health problems. Several studies have explored the association between ASD and FA, but the conclusions were inconsistent. The aim of this review was to evaluate the relationship between ASD and FA. The PubMed, Embase, and Web of Science databases were searched from inception to February 2, 2020. Studies investigating the association between ASD and FA were included. A random effects model was used to pool risk estimates. Subgroup analysis and sensitivity analysis were used to explore the potential sources of heterogeneity. Fifteen studies with a total of 293,130 participants were included in this review. The pooled prevalence of FA in individuals with ASD was 13% (95% confidence interval (CI): 0.10–0.17), while the pooled prevalence of FA in controls was 5% (95% CI: 0.04–0.07). The pooled odds ratio (OR) for FA in individuals with ASD was 2.45 (95% CI: 2.25–2.67). One study examined the prevalence of ASD in participants with FA. The prevalence of ASD in individuals with FA was 3.5% (95% CI: 0.029–0.042), while the prevalence of ASD in the control group was 1.6% (95% CI: 0.015–0.017). Five study examined the OR of ASD in participants with FA. The OR for ASD in individuals with FA was 1.95 (95% CI: 1.73–2.19). The results of this systematic review and meta‐analysis seem to reveal a significant association between ASD and FA.

中文翻译：

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自闭症谱系障碍与食物过敏之间的关联：系统评价和荟萃分析

自闭症谱系障碍（ASD）和食物过敏（FA）是全球公共卫生问题。几项研究探讨了ASD与FA之间的关系，但结论并不一致。这篇综述的目的是评估ASD和FA之间的关系。从开始到2020年2月2日，搜索PubMed，Embase和Web of Science数据库。其中包括调查ASD和FA之间关联的研究。使用随机效应模型来汇总风险估计。亚组分析和敏感性分析被用来探索异质性的潜在来源。本评价纳入了15项研究，共有293,130名参与者。ASD患者的FA合并患病率为13％（95％置信区间（CI）：0.10-0.17），而对照组中FA合并患病率为5％（95％CI：0.04-0.07）。ASD患者FA的合并比值比（OR）为2.45（95％CI：2.25-2.67）。一项研究检查了FA参与者中ASD的患病率。患有FA的个体的ASD患病率为3.5％（95％CI：0.029-0.042），而对照组的ASD患病率为1.6％（95％CI：0.015-0.017）。五项研究检查了FA参与者中ASD的OR。患有FA的个体的ASD的OR为1.95（95％CI：1.73–2.19）。这项系统评价和荟萃分析的结果似乎表明ASD与FA之间存在显着关联。015–0.017）。五项研究检查了FA参与者中ASD的OR。患有FA的个体的ASD的OR为1.95（95％CI：1.73–2.19）。这项系统评价和荟萃分析的结果似乎表明ASD与FA之间存在显着关联。015–0.017）。五项研究检查了FA参与者中ASD的OR。患有FA的个体的ASD的OR为1.95（95％CI：1.73–2.19）。这项系统评价和荟萃分析的结果似乎表明ASD与FA之间存在显着关联。