Cellular senescence is a widespread cellular programme that is characterized by permanent cell cycle arrest. Senescent cells adopt a changed secretory phenotype that can alter cellular function. For years, cellular senescence has been thought to be a protective factor against cancer; however, it is now recognized that it has a dual effect on individuals. Co‐ordinated activation of cellular senescence provides advantages during embryogenesis, wound healing, tissue repair and inhibition of tumorigenesis. On the other hand, the aberrant generation and accumulation of abnormal senescent cells lead to the development of age‐related conditions and tissue deterioration. During acute kidney injury (AKI), the kidney faces multiple types of stressors and challenges, which can easily drive cellular senescence. How to appropriately progress through the cell cycle and minimize long‐term damage is of great importance to the acquisition of adaptive repair considering that no available therapeutic interventions can reliably limit injury, speedy recovery or improve the prognosis of this syndrome. Whether the manipulation of cellular senescence can become a novel therapeutic target in AKI and reignite clinical and research interest remains to be determined. Here, we share our current understanding of the role of cellular senescence in AKI, along with examples of the application of mesenchymal stem cells (MSCs) for targeting this disorder during its treatment.

中文翻译：

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细胞衰老，间充质干细胞在急性肾脏损伤中的新型治疗靶点

细胞衰老是一种广泛的细胞程序，其特征在于永久性细胞周期停滞。衰老细胞采用改变的分泌表型，可以改变细胞功能。多年来，细胞衰老一直被认为是抗癌的保护因素。但是，现在人们认识到它对个人具有双重影响。细胞衰老的协同激活在胚胎发生，伤口愈合，组织修复和肿瘤发生抑制方面具有优势。另一方面，异常衰老细胞的异常产生和积累导致与年龄有关的疾病的发展和组织退化。在急性肾损伤（AKI）期间，肾脏面临多种压力源和挑战，这很容易导致细胞衰老。考虑到没有可用的治疗干预措施能够可靠地限制损伤，迅速康复或改善该综合征的预后，如何适当地推进细胞周期并最大程度地减少长期损害对适应性修复至关重要。细胞衰老的控制是否可以成为AKI的新治疗靶点并重新激发临床和研究兴趣尚待确定。在这里，我们分享了我们目前对AKI中细胞衰老的作用的理解，以及间充质干细胞（MSCs）在治疗该疾病中针对该疾病的应用实例。快速恢复或改善该综合征的预后。细胞衰老的控制是否可以成为AKI的新型治疗靶点并重新激发临床和研究兴趣尚待确定。在这里，我们分享了我们目前对AKI中细胞衰老的作用的理解，以及间充质干细胞（MSCs）在治疗该疾病中针对该疾病的应用实例。快速恢复或改善该综合征的预后。细胞衰老的控制是否可以成为AKI的新治疗靶点并重新激发临床和研究兴趣尚待确定。在这里，我们分享了我们目前对AKI中细胞衰老的作用的理解，以及间充质干细胞（MSCs）在治疗该疾病中针对该疾病的应用实例。